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首页> 外文期刊>Circulation journal >Circulating Factor VII Activating Protease (FSAP) Is Associated With Clinical Outcome in Acute Coronary Syndrome
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Circulating Factor VII Activating Protease (FSAP) Is Associated With Clinical Outcome in Acute Coronary Syndrome

机译：循环因子VII激活蛋白酶（FSAP）与急性冠脉综合征的临床结果相关

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Background: ?Factor VII activating protease (FSAP) is a circulating serine protease strongly expressed in unstable plaques and may serve as a marker of plaque destabilization. The aim of this study was to examine the relation between plasma concentrations of FSAP and clinical instability and outcome in coronary artery disease (CAD). Methods and Results: ?Circulating FSAP concentration and activity, as well as FSAP mRNA expression in monocytes, were measured in 231 sequential patients who underwent coronary angiography because of stable angina pectoris (n=50), unstable angina pectoris (n=43), or acute myocardial infarction (n=87). FSAP activity, but not FSAP antigen concentration, was elevated in patients with CAD compared with a control group. Elevated FSAP activity (≥1.035 plasma equivalent units [PEU]/ml) indicated a significantly increased risk of death or non-fatal myocardial infarction during 1 year of follow-up as compared with patients with low activity of FSAP (odds ratio 1.895 [95% confidence interval 1.093–3.283]; P=0.023). Furthermore, there were no significant changes in the FSAP expression in monocytes from CAD and control subjects in the basal state but there were differences after stimulation with proinflammatory factors. Conclusions: ?Plasma FSAP activity was significantly increased in patients with acute coronary syndrome and may be involved in the pathogenesis of these conditions. High levels of FSAP activity were predictive of adverse events during follow-up, suggesting its potential role in risk stratification and clinical management of CAD patients.??(Circ J?2012; 76: 2653–2661)
机译：背景：因子VII活化蛋白酶（FSAP）是一种在不稳定斑块中强烈表达的循环丝氨酸蛋白酶，可作为斑块不稳定的标志。这项研究的目的是检查血浆FSAP浓度与冠状动脉疾病（CAD）临床不稳定性和预后之间的关系。方法和结果：对231例因稳定型心绞痛（n = 50），不稳定型心绞痛（n = 43）进行冠状动脉造影的序贯患者进行了循环FSAP浓度和活性以及FSAP mRNA表达的测定。或急性心肌梗塞（n = 87）。与对照组相比，CAD患者的FSAP活性升高，但FSAP抗原浓度升高。 FSAP活性升高（≥1.035血浆当量单位[PEU] / ml）表明，与FSAP活性低的患者相比，随访1年内死亡或非致命性心肌梗塞的风险显着增加（优势比1.895 [95] ％置信区间1.093-3.283]; P = 0.023）。此外，在基础状态下，来自CAD和对照组的单核细胞在基础状态下的FSAP表达没有明显变化，但是在促炎因子刺激后，FSAP表达存在差异。结论：急性冠脉综合征患者血浆FSAP活性显着升高，可能与这些疾病的发病机制有关。高水平的FSAP活动可预测随访期间的不良事件，表明其在CAD患者的风险分层和临床管理中的潜在作用。（Circ J？2012; 76：2653-2661）

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