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首页> 外文期刊>Circulation journal >Atorvastatin Accelerates Both Neointimal Coverage and Re-Endothelialization After Sirolimus-Eluting Stent Implantation in a Porcine Model – New Findings From Optical Coherence Tomography and Pathology –
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Atorvastatin Accelerates Both Neointimal Coverage and Re-Endothelialization After Sirolimus-Eluting Stent Implantation in a Porcine Model – New Findings From Optical Coherence Tomography and Pathology –

机译：在猪模型中西罗莫司洗脱支架植入后，阿托伐他汀可加速新内膜覆盖和重新内皮化–光学相干断层扫描和病理学的新发现–

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Background: ?Delayed vessel healing after drug-eluting stent implantation is thought to be the underlying mechanisms of late stent thrombosis (LST). Methods and Results: ?In the animal model of stenting, 45 minipigs were divided into 3 groups (n=15 each): bare metal stent (BMS), sirolimus-eluting stent (SES), and SES plus atorvastatin treatment (SES+ator). Neointimal coverage and endothelium coverage were evaluated separately by optical coherence tomography (OCT), pathology, and scanning electron microscopy (SEM) at days 7, 14 and 28. OCT showed that SES significantly delayed neointimal coverage compared with BMS and the percentage of uncovered struts in the SES+ator group was significantly decreased on days 7 (42.7±1.3% vs. 56.8±5.7%, P
机译：背景：？药物洗脱支架植入后的血管延迟愈合被认为是晚期支架血栓形成（LST）的潜在机制。方法和结果：？在置入支架的动物模型中，将45只小型猪分为3组（每组15只）：裸金属支架（BMS），西罗莫司洗脱支架（SES）和SES加阿托伐他汀治疗（SES + ator） ）。在第7、14和28天通过光学相干断层扫描（OCT），病理学和扫描电子显微镜（SEM）分别评估了新内膜的覆盖率和内皮覆盖率。OCT显示，与BMS相比，SES显着延迟了新内膜的覆盖率和未覆盖的支撑物的百分比SES + ator组的第7天显着下降（42.7±1.3％vs. 56.8±5.7％，P

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