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首页> 外文期刊>Circulation journal >Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease　― Post Hoc Analysis of the FMD-J Study A ―
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Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease　― Post Hoc Analysis of the FMD-J Study A ―

机译：甘油三酸酯作为冠心病患者心血管事件残留风险的目标― FMD-J研究A的事后分析―

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Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy. Methods?and?Results: We analyzed data for 652 patients who were enrolled in the FMD-J Study A. We investigated the associations between serum TG levels and first major CV events (death from CV cause, nonfatal acute coronary syndrome (ACS), nonfatal stroke, and CAD) for a 3-year follow-up period. Patients were divided into 4 groups based on serum TG level: low-normal (100 mg/dL), high-normal (100–149 mg/dL), borderline hypertriglyceridemia (150–199 mg/dL), and moderate hypertriglyceridemia (≥200 mg/dL). During a median follow-up period of 46.6 months, 14 patients died (9 from CV causes), 16 had nonfatal ACS, 6 had nonfatal stroke, and 54 had CAD. The Kaplan-Meier curves for first major CV event among the 4 groups were significantly different (P=0.04). After adjustment for various confounders, serum TG level ≥100 mg/dL were significantly associated with an increased risk of first major CV events compared with serum TG level 100 mg/dL. Conclusions: Serum TG level may be a surrogate marker for predicting CV events in patients with CAD.
机译：背景：循环中的甘油三酸酯（TG）水平是当前关注的重点，是心血管事件（CV）事件的残留风险。我们评估了接受常规治疗的冠心病患者的循环TG水平与未来CV事件之间的关系。方法和结果：我们分析了参加FMD-J研究A的652例患者的数据。我们调查了血清TG水平与首次主要CV事件（因CV病死，非致命性急性冠脉综合征（ACS），非致命性卒中和CAD），为期3年的随访期。根据血清TG水平将患者分为4组：低正常（<100 mg / dL），高正常（100–149 mg / dL），临界高甘油三酯血症（150–199 mg / dL）和中度高甘油三酯血症（ ≥200mg / dL）。在46.6个月的中位随访期中，有14例患者死亡（9例由于CV原因），非致命性ACS死亡16例，非致命性中风死亡6例，CAD死亡54例。 4组中第一个主要CV事件的Kaplan-Meier曲线存在显着差异（P = 0.04）。在对各种混杂因素进行调整后，与血清TG水平<100 mg / dL相比，血清TG水平≥100mg / dL与首次重大CV事件发生的风险增加显着相关。结论：血清TG水平可能是预测CAD患者心血管事件的替代指标。

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