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首页> 外文期刊>Circulation journal >In-Depth Insight Into the Mechanisms of Cardiac Dysfunction in Patients With Type 1 Diabetes Mellitus Using Layer-Specific Strain Analysis
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In-Depth Insight Into the Mechanisms of Cardiac Dysfunction in Patients With Type 1 Diabetes Mellitus Using Layer-Specific Strain Analysis

机译：使用层特定应变分析深入了解1型糖尿病患者心脏功能障碍的机制

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Background: Although the subclinical left ventricular (LV) dysfunction caused by diabetes mellitus (DM) results in a high risk of death and heart failure, the details of cardiac dysfunction across a wide age range remain unclear. The aim of this study was to assess LV dysfunction in patients with type 1 DM (T1DM) using layer-specific strain analysis by echocardiography. Methods?and?Results: The 52 patients (median age: 23 [range: 5–40] years) with T1DM were divided into 3 age groups (D1: 5–14 years, D2: 15–24 years, D3: 25–40 years); 78 age- and sex-similar controls were divided into 3 corresponding groups (C1, C2, and C3). Layer-specific longitudinal strain (LS) and circumferential strain (CS) of the 3 myocardial layers (endocardium, midmyocardium, and epicardium) were determined using echocardiography. Strains did not decrease in D1. Epicardial and midmyocardial CS at the basal level and LS in all layers were decreased in D2 compared with C2. CS at the basal level and LS in all layers were lower in D3 than in C3. The strains correlated with the duration of T1DM and LV wall thickness. Conclusions: In patients with T1DM, longitudinal deformation in all layers and epicardial and midmyocardial circumferential deformation at the basal level decreased from the late teens, which correlated with the duration of the disease and LV hypertrophy.
机译：背景：尽管由糖尿病（DM）引起的亚临床左心室（LV）功能障碍会导致死亡和心力衰竭的高风险，但对于广泛年龄段的心脏功能障碍的细节仍不清楚。这项研究的目的是通过超声心动图的层特异性应变分析来评估1型糖尿病（T1DM）患者的左室功能障碍。方法和结果：52例T1DM患者（中位年龄：23​​ [范围：5-40]岁）分为3个年龄组（D1：5-14岁，D2：15-24岁，D3：25-岁）。 40年）;将78个年龄和性别相似的对照组分为3个相应的组（C1，C2和C3）。使用超声心动图确定三个心肌层（心内膜，中层心肌和心外膜）的层特异性纵向应变（LS）和周向应变（CS）。 D1株没有减少。与C2相比，D2的基础水平心外膜和心肌中层CS和所有层的LS均降低。 D3的基础水平的CS和所有层的LS均低于C3。应变与T1DM的持续时间和LV壁厚有关。结论：T1DM患者从青少年晚期开始，各层的纵向变形以及基础水平的心外膜和心肌中部圆周变形都减少了，这与疾病的持续时间和左室肥大有关。

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