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首页> 外文期刊>Case Reports in Obstetrics and Gynecology >Ependymoma and Carcinoid Tumor Associated with Ovarian Mature Cystic Teratoma in a Patient with Multiple Endocrine Neoplasia I
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Ependymoma and Carcinoid Tumor Associated with Ovarian Mature Cystic Teratoma in a Patient with Multiple Endocrine Neoplasia I

机译：伴有多发性内分泌肿瘤的卵巢成熟囊性畸胎瘤的室间隔瘤和类癌瘤

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摘要

Ovarian teratomas rarely undergo new neoplastic transformation and account for a small percentage of malignant ovarian germ cell neoplasms. Here we report a case of a 51-year-old woman with multiple endocrine neoplasia type I (MEN I) who was found to have an ependymoma and neuroendocrine tumor (trabecular carcinoid) associated with mature cystic teratoma of her left ovary. The ependymoma component displayed cells with round nuclei and occasional small nucleoli which were focally arranged in perivascular pseudorosettes and true rosettes. Rare mitoses were identified. No necrosis was present. Immunohistochemical staining was positive for S-100 and GFAP. The Ki67 proliferation index was very low (2-3%). In contrast, the endocrine tumor component was composed of small uniform cells with eosinophilic cytoplasm, round nuclei, and speckled chromatin. Immunohistochemical staining was positive for synaptophysin and focally positive for chromogranin. This rare case illustrates that MEN I may have an influence on the pathogenesis of ovarian teratomas as they undergo malignant transformation.
机译：卵巢畸胎瘤很少经历新的肿瘤转化，占卵巢恶性生殖细胞肿瘤的一小部分。在这里，我们报告了一个患有多发性内分泌肿瘤I型（MEN I）的51岁女性的病例，发现该患者患有与她的左卵巢成熟的囊性畸胎瘤相关的室间隔瘤和神经内分泌肿瘤（小梁类癌）。室管膜瘤成分显示细胞核圆形，偶有小核仁，它们集中排列在血管周假玫瑰花结和真玫瑰花结中。确定了罕见的有丝分裂。没有坏死存在。免疫组织化学染色显示S-100和GFAP阳性。 Ki67增殖指数非常低（2-3％）。相比之下，内分泌肿瘤成分由具有嗜酸性细胞质，圆形核和斑点染色质的小的均匀细胞组成。免疫组化染色显示突触素阳性，嗜铬粒蛋白则局部阳性。这种罕见的情况说明，MEN I可能在卵巢畸胎瘤发生恶性转化时对其发病机制产生影响。

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