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首页> 外文期刊>Case Reports in Nephrology and Dialysis >Neurotoxicity following the Ingestion of Bilimbi Fruit (Averrhoa bilimbi) in an End-Stage Renal Disease Patient on Hemodialysis
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Neurotoxicity following the Ingestion of Bilimbi Fruit (Averrhoa bilimbi) in an End-Stage Renal Disease Patient on Hemodialysis

机译：终末期肾脏疾病患者接受血液透析后摄入Bilimbi水果（Averrhoa bilimbi）后的神经毒性

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Introduction: The toxic effects of the ingestion of star fruit (Averrhoa carambola) in chronic kidney disease patients are well described in the literature. Recently, the compound caramboxin has been isolated, explaining the mechanisms of its neurotoxicity. Bilimbi fruit belongs to the family Oxalidaceae, Averrhoa bilimbi species, and exhibits similar biochemical characteristics to star fruit. Objective: To report the case of a patient with chronic kidney disease who developed a seizure disorder after the ingestion of bilimbi fruit. Case Report: A 69-year-old man with chronic kidney disease on hemodialysis therapy had intractable hiccups, myoclonus, and generalized tonic-clonic seizures after the consumption of a moderate amount of bilimbi fruit. The electroencephalogram showed a pattern of seizure disorder despite the use of anticonvulsant drugs. Renal replacement therapy was maintained during the whole period and prescribed according to the patient’s hemodynamic status. Despite showing clinical resolution of the seizure disorder, the patient died on the 27th day of hospitalization for infectious complications. Conclusions: The neurologic status without any other known cause and with clear temporal association with the ingestion of the fruit suggests the diagnosis of neurotoxicity. We propose the hypothesis that the bilimbi fruit has neurotoxic effects similar to those exhibited by the star fruit.
机译：简介：摄入杨桃（杨桃）对慢性肾脏病患者的毒性作用在文献中已有很好的描述。最近，已分离出化合物caramboxin，解释了其神经毒性的机理。 Bilimbi水果属于Oxalidaceae，Averrhoa bilimbi物种，具有与杨桃相似的生化特性。目的：报告一例患有慢性肾脏疾病的患者，该患者在摄入双利比水果后出现癫痫发作。病例报告：一名接受血液透析治疗的患有慢性肾脏疾病的69岁男子在食用适量的Bilimbi水果后出现顽固的打ic，肌阵挛和全身性强直-阵挛性癫痫发作。尽管使用了抗惊厥药物，脑电图仍显示出癫痫发作的模式。整个过程中均应维持肾脏替代疗法，并根据患者的血液动力学状况进行处方。尽管表现出癫痫发作的临床解决方案，该患者仍在住院的第27天因感染并发症而死亡。结论：没有其他已知原因的神经系统状态，与摄入水果有明显的时间相关性，提示神经毒性的诊断。我们提出了这样的假说，即双limbi水果具有类似于杨桃所表现出的神经毒性作用。

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