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首页> 外文期刊>Case Reports in Nephrology and Dialysis >Oxcarbazepine Therapy for Complete Central Diabetes Insipidus
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Oxcarbazepine Therapy for Complete Central Diabetes Insipidus

机译：奥卡西平治疗完全性中枢性尿崩症

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摘要

Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic hormone (ADH) levels. This suggests that oxcarbazepine (or one of its metabolites) may stimulate collecting tubule V2 receptor-G protein complex independent of ADH, resulting in increased renal tubular water reabsorption. Oxcarbazepine may be useful as an alternative therapy for patients with central diabetes insipidus.
机译：奥卡西平和卡马西平通过未知机制引起低钠血症。我们描述了患有完全中枢性尿崩症和癫痫发作的患者，当奥卡西平的剂量增加时，其发展为低钠血症。尽管未检测到抗利尿激素（ADH）的水平，但患者维持正常的血清钠水平，仅使用奥卡西平就已适当浓缩了5年的尿液。这表明奥卡西平（或其代谢物之一）可能刺激独立于ADH的收集小管V2受体-G蛋白复合物，导致肾小管对水的重吸收增加。奥卡西平可作为中枢性尿崩症患者的替代疗法。

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