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A Very Rare Case: HPV-Negative Vulvar Cancer in an Adolescent

机译:一个非常罕见的案例:青少年HPV阴性外阴癌

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Carcinoma of the vulva is usually regarded as a disease of older women, with the typical age of 65–85 years. There are a limited number of reports of vulvar cancer cases younger than 30 years. These patients have usually risk factors such as human papillomavirus (HPV) infection and immunosuppression. Herein, we present a case of invasive squamous vulvar cancer in an 18-year-old patient without any risk factor. Vulvar radical local excision and bilateral inguinal sentinel lymph node biopsies were performed. The clitoris was preserved during the surgery. Patient did not receive adjuvant therapy. Follow-up after 12 months of the disease showed no evidence of disease. Vulvar carcinoma in very young women may develop without any predisposing factor. Early detection will result in better survival. So, there should be a high index of suspicion when a vulvar lesion is seen, even if the patient falls below the typical age range and does not carry any well-known risk factors such as HPV infection and immunodeficiency.
机译:外阴癌通常被认为是老年女性的疾病,典型年龄为65-85岁。关于30岁以下的外阴癌病例的报道很少。这些患者通常具有人类乳头瘤病毒(HPV)感染和免疫抑制等危险因素。在此,我们介绍了一名18岁患者的浸润性外阴鳞癌病例,无任何危险因素。进行外阴根治性局部切除和双侧腹股沟前哨淋巴结活检。手术期间保留了阴蒂。患者未接受辅助治疗。疾病12个月后的随访未发现疾病迹象。在非常年轻的女性中,外阴癌可能没有任何诱发因素地发展。尽早发现将带来更好的生存。因此,即使患者跌落到典型年龄范围并且没有携带任何众所周知的危险因素,例如HPV感染和免疫缺陷,当发现外阴病变时也应高度怀疑。

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