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首页> 外文期刊>Case Reports in Obstetrics and Gynecology >Long-Acting Luteinizing Hormone-Releasing Hormone Agonist for Ovarian Hyperstimulation Induced by Tamoxifen for Breast Cancer
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Long-Acting Luteinizing Hormone-Releasing Hormone Agonist for Ovarian Hyperstimulation Induced by Tamoxifen for Breast Cancer

机译：长效促黄体激素释放激素激动剂对他莫昔芬诱导的乳腺癌卵巢过度刺激的作用

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Tamoxifen treatment for breast cancer may induce ovarian cysts and supraphysiological levels of serum estrogen. We report successful management with luteinizing hormone-releasing hormone (LHRH) agonist of ovarian hyperstimulation induced by tamoxifen. A 49-year-old woman was operated on for invasive ductal carcinoma of the right breast. She received breast irradiation and adjuvant tamoxifen therapy. After 2 years, she had a cystic ovarian mass, and her serum concentration of estradiol was 1280 pg/mL. She was treated with an injection of 11.25 mg leuprolide acetate, a long-acting LHRH agonist, without abandoning tamoxifen therapy. The levels of estradiol decreased to <10 pg/mL and the cystic mass disappeared 2 months later. Three-month depot treatment with LHRH agonists can be useful for patients receiving tamoxifen for breast cancer who have ovarian cysts and supraphysiological levels of estrogen.
机译：他莫昔芬治疗乳腺癌可能会诱发卵巢囊肿和血清雌激素的超生理水平。我们报告了由他莫昔芬诱导的卵巢过度刺激的促黄体激素释放激素（LHRH）激动剂的成功管理。一名49岁妇女因右乳房浸润性导管癌接受手术治疗。她接受了乳房照射和他莫昔芬的辅助治疗。 2年后，她有卵巢囊性肿块，血清雌二醇浓度为1280 pg / mL。她接受了11.25mg醋酸亮丙瑞林（一种长效LHRH激动剂）的注射治疗，但未放弃他莫昔芬疗法。雌二醇水平降至<10μg/ mL，2个月后囊肿消失。用LHRH激动剂进行的为期三个月的储库治疗对于接受他莫昔芬治疗的患有卵巢囊肿和超生理水平雌激素的乳腺癌患者可能有用。

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