Insulin-like growth factor-1 enhances mortality risk in women with breast cancer through epithelial-mesenchymal transition initiation

Ala-Eddin Al Moustafa

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Insulin-like growth factor-1 enhances mortality risk in women with breast cancer through epithelial-mesenchymal transition initiation

机译：胰岛素样生长因子-1通过上皮-间质转化的启动增加乳腺癌女性的死亡风险

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The metastatic disease which leads to cancer patients' mortality results from a multi-step process of tumor progression caused by gene alteration and cooperation. Accordingly, it was recently demonstrated that alteration level of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) are associated with the risk of cancer related death in several human malignancies including breast cancer. On the other hand, epithelial-mesenchymal transition (EMT) is described as a crucial event in cancer progression and metastasis. Herein, we discuss the association between IGF-1, IGF-1/IGFBP-3 ratio, EMT, and breast cancer mortality.

机译：导致癌症患者死亡的转移性疾病，是由于基因改变和协同作用导致肿瘤发展的多步骤过程所致。因此，最近证明，胰岛素样生长因子-1（IGF-1）和IGF结合蛋白-3（IGFBP-3）的改变水平与包括乳腺癌在内的几种人类恶性肿瘤中与癌症相关的死亡风险相关。另一方面，上皮-间质转化（EMT）被描述为癌症进展和转移中的关键事件。在本文中，我们讨论了IGF-1，IGF-1 / IGFBP-3比，EMT和乳腺癌死亡率之间的关联。

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《Clinical Cancer Investigation Journal》 |2013年第3期|共3页
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Ala-Eddin Al Moustafa;
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中图分类肿瘤学;
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1. Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from her [J] . Jernstrom H, Sandberg T, Bageman E, International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2006,第Suppla2期

机译：胰岛素样生长因子-1基因型可预测妊娠和激素避孕后的乳房体积，并与循环的胰岛素样生长因子-1水平相关：其年轻女性对早发性乳腺癌风险的影响
2. Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with similar to 430 000 women [J] . Annals of oncology: official journal of the European Society for Medical Oncology . 2020,第5期

机译：胰岛素样生长因子-1，胰岛素样生长因子结合蛋白-3，以及乳腺癌风险：观察和孟德尔随机化分析与430 000名女性相似
3. Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families [J] . H Jernstr?m, T Sandberg, E B?geman, British Journal of Cancer . 2005,第5期

机译：胰岛素样生长因子-1（IGF1）基因型可预测妊娠和激素避孕后的乳房体积，并与循环中的IGF-1水平相关：遗传性乳腺癌家族的年轻女性对早发性乳腺癌风险的影响
4. EVALUATION OF INSULIN-LIKE GROWTH FACTOR-1 AND PARATHYROID HORMONE ON GROWTH CHARACTERISTICS OF MG-63 CELLS [C] . Laura Franklin, Lisa Haynie, Joel Davis, Annual Rocky Mountain Bioengineering Symposium . 2005

机译：评估胰岛素样生长因子-1和甲状旁腺激素对MG-63细胞生长特性的评价
5. Development of an insturmal method to evaluate insulin receptors and insulin-like growth factor-1 receptors homodimers and hybrid receptors in breast cancer. [D] . Shebani, Karima A. 2016

机译：开发了一种评估乳腺癌中胰岛素受体和胰岛素样生长因子-1受体同型二聚体和杂合受体的可靠方法。
6. Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families [O] . H Jernström, T Sandberg, E Bågeman, 2005

机译：胰岛素样生长因子-1（IGF1）基因型可预测妊娠和激素避孕后的乳房体积并与循环中的IGF-1水平相关：遗传性乳腺癌家族中年轻女性患早发乳腺癌的风险
7. Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ∼430 000 women [O] . N. Murphy, A. Knuppel, N. Papadimitriou, 2020

机译：胰岛素样生长因子-1，胰岛素样生长因子结合蛋白-3，以及乳腺癌风险：观察和孟德尔随机化分析与~430 000女性分析

Insulin-like growth factor-1 enhances mortality risk in women with breast cancer through epithelial-mesenchymal transition initiation

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