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首页> 外文期刊>Clinical and Translational Allergy >Strong association between hla-a*02:06 and acetaminophen-related stevens-johnson syndrome with severe mucosal involvements in the Japanese
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Strong association between hla-a*02:06 and acetaminophen-related stevens-johnson syndrome with severe mucosal involvements in the Japanese

机译：在日本，hla-a * 02：06与对乙酰氨基酚相关的史蒂文斯-约翰逊综合征与严重的粘膜受累之间有很强的联系

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BackgroundStevens-Johnson syndrome (SJS) and its severe variant,toxic epidermal necrolysis (TEN), are acute inflammatoryvesiculobullous reactions of the skin and mucousmembranes of, for example, the ocular surface, oral cavity,and genitals. They are rare but often associated with incitingdrugs. Cold medicines including non-steroidal antiinflammatorydrugs (NSAIDs) and multi-ingredient coldmedications are reported to be important inciting drugs.We investigated the association between HLA genotypesand cold medicine-related SJS/TEN (CM-SJS/TEN) withsevere mucosal involvement such as severe ocular surfacecomplications (SOC). We also investigated the associationbetween HLA genotypes and acetaminophen-related SJS/TEN in patients with CM-SJS/TEN with SOC.MethodsJapanese acetaminophen-related SJS/TEN patients consistof 59 patients, they were among the 131 CM-SJS/TENwith SOC. While the specific drugs were not named byall 131 patients, 59 (45.0%) were known to have takenmedicines containing acetaminophen. The diagnosis ofSJS/TEN with SOC was based on a confirmed history ofacute-onset high fever, serious mucocutaneous illnesswith skin eruptions, and the involvement of at least 2mucosal sites including the oral cavity and ocular surface.We analyzed HLA-A, -B, and -C of 131 CM-SJS/TENpatients and 419 Japanese controls.ResultsHLA-A*02:06 was strongly associated with CM-SJS/TENwith SOC (carrier frequency: p=2.8X10-16, Pc=4.8X10-15,OR=5.7), and the odds ratio was highest for acetaminophen-related SJS/TEN with SOC (carrier frequency:p=5.0X10-13, Pc=8.5X10-12, OR=7.0).ConclusionElucidating the predisposition to drug-induced severecutaneous adverse reactions might make it possible toprevent drug-induced severe cutaneous adverse reactionswith avoiding the risk drug from the person having thepredisposition.
机译：背景史蒂文斯-约翰逊综合症（SJS）及其严重的变异形式是毒性表皮坏死溶解（TEN），是皮肤和粘膜（例如眼表，口腔和生殖器）的急性炎性囊泡性反应。它们很少见，但经常与煽动性毒品有关。据报道，包括非甾体类抗炎药（NSAIDs）和多成分感冒药在内的感冒药是重要的诱人药物。我们调查了HLA基因型与感冒药相关的SJS / TEN（CM-SJS / TEN）与严重粘膜受累（例如严重）之间的关联眼表面并发症（SOC）。我们还调查了患有SOC的CM-SJS / TEN患者中HLA基因型与对乙酰氨基酚相关SJS / TEN的关系。方法日本对乙酰氨基酚相关SJS / TEN患者由59例患者组成，属于131例CM-SJS / TEN伴SOC的患者。尽管所有131例患者均未指定具体药物，但已知59例（45.0％）服用了含有对乙酰氨基酚的药物。 SOC的SJS / TEN诊断基于确诊的急性发高烧，严重的皮肤粘膜疾病伴皮肤爆发，以及至少2个黏膜部位（包括口腔和眼表）受累的历史。我们分析了HLA-A，-B，结果131名CM-SJS / TEN患者和419名日本对照患者的-C。结果HLA-A * 02：06与带有SOC的CM-SJS / TEN密切相关（载波频率：p = 2.8X10-16，Pc = 4.8X10-15， OR = 5.7），且对乙酰氨基酚相关SJS / TEN的SOC的比值比最高（载波频率：p = 5.0X10-13，Pc = 8.5X10-12，OR = 7.0）。结论严重的皮肤不良反应可能使得有可能预防药物引起的严重的皮肤不良反应，同时避免来自易感者的危险药物。

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