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首页> 外文期刊>Clinical Interventions in Aging >Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole
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Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole

机译：在中国老年患者中治疗消化性溃疡和胃食管反流疾病–关注埃索美拉唑

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摘要

Abstract: Peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are not uncommon in elderly patients. Clinical presentations of these acid-related disorders may be atypical in the geriatric population. Older individuals are at increased risk for poor outcomes in complicated PUD and for development of GERD complications. Multiple risk factors (eg, Helicobacter pylori [HP], use of nonsteroidal anti-inflammatory drugs [NSAIDs], aspirin) contribute to the development of PUD. Recent data has shown that HP-negative, NSAID-negative idiopathic peptic ulcers are on the rise and carry a higher risk of recurrent ulcer bleeding and mortality. Effective management of PUD in the geriatric population relies on identification and modification of treatable risk factors. Elderly patients with GERD often require long-term acid suppressive therapy. Proton pump inhibitors (PPI) including esomeprazole are effective in the treatment of reflux esophagitis, maintenance of GERD symptomatic control, and management of PUD as well as its complications. Potential safety concerns of long-term PPI use have been reported in the literature. Clinicians should balance the risks and benefits before committing elderly patients to long-term PPI therapy.
机译：摘要：老年患者的消化性溃疡病（PUD）和胃食管反流病（GERD）并不少见。这些与酸有关的疾病的临床表现在老年人群中可能是非典型的。老年人在复杂的PUD中不良结局和GERD并发症发生的风险增加。多种危险因素（例如幽门螺杆菌[HP]，使用非甾体抗炎药[NSAIDs]，阿司匹林）有助于PUD的发展。最近的数据表明，HP阴性，NSAID阴性的特发性消化性溃疡呈上升趋势，且溃疡复发和死亡的风险更高。老年人群中PUD的有效管理取决于可治疗风险因素的识别和修改。患有GERD的老年患者通常需要长期的抑酸治疗。包括埃索美拉唑的质子泵抑制剂（PPI）可有效治疗反流性食管炎，维持GERD症状控制，治疗PUD及其并发症。文献中已经报道了长期使用PPI可能引起的安全隐患。在让老年患者接受长期PPI治疗之前，临床医生应权衡风险和收益。

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