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New allergy drug excipient allergy

机译：新过敏药物赋形剂过敏

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BackgroundBecause of its rarity, drug excipients allergy is oftenunsuspected by the doctors. Some times the active drugis blamed and discontinued unnecessarily when the realculprit is drug excipients. This was suspected whenpatients reported exacerbation of urticaria with anti histaminicwhich are actually used for treating urticaria.After suspecting drug excipient as the cause of allergy.MaterialTo know actual cause it was decided to do patch testingwith common drug excipients. The common excipientselected were Yellow Tartrazine, Titanium Dioxide, SunsetYellow, Brilliant Blue, Quinolone Yellow, Talcum, andPonaceue 4R.MethodPatch testing material were prepared by using the basicmaterial and suitable vehicle. 24 patients were selectedfor patch testing. Patch was put on patients back after48 hrs reading were taken to confirm the skinsensitivities.ResultOut of 24 patients 15 patients were positive for YellowTartrazine only, 3 patients showed positive to TitaniumDioxide. 2 patients were positive to Quinolone Yellowand Talcum. 2 were positive with Brilliant blue.3 patients were positive Yellow Tartrazine, Sunsets Yellowand Talcum.ConclusionDrug excipients play an important role in causation isrequired to be standardised for patch testing. This type ofpatients should be treated in view of such investigationsand preferably treated with drug without excipients.
机译：背景技术由于药物赋形剂的罕见性，因此医生通常不会对其过敏。有时，当真正的罪魁祸首是药物赋形剂时，会归咎于活性药物而不必要地停药。当患者报告有抗组胺药加重荨麻疹而实际上是用于治疗荨麻疹时，就怀疑了这一点。在怀疑药物赋形剂是引起过敏的原因之后。材料要知道实际原因，决定对普通药物赋形剂进行斑贴试验。常用的赋形剂为黄色酒石黄，二氧化钛，日落黄，亮蓝，喹诺酮黄，滑石粉和Ponaceue 4R。选择24例患者进行斑贴试验。在阅读48小时后，将贴剂放回患者身上以确认其皮肤敏感性。结果24例患者中有15例仅对YellowTartrazine呈阳性，其中3例对二氧化钛呈阳性。 2例患者对喹诺酮黄和滑石粉呈阳性。亮蓝2例阳性，黄酒石黄，日落黄和滑石粉阳性3例。结论药物赋形剂在因果关系中起着重要作用，需要标准化以进行斑贴试验。此类患者应根据此类调查进行治疗，最好使用不含赋形剂的药物治疗。

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