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首页> 外文期刊>Clinical and Translational Allergy >Inclusion of clavulanic acid determinants in the basophil activation test improves the evaluation of immediate reactions to amoxicillin-clavulanic acid
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Inclusion of clavulanic acid determinants in the basophil activation test improves the evaluation of immediate reactions to amoxicillin-clavulanic acid

机译：嗜碱性粒细胞活化试验中加入克拉维酸决定因素可改善对阿莫西林-克拉维酸立即反应的评估

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BackgroundThe clavulanic acid (CLV) is nowadays frequently includedin the treatment with Amoxicillin (AX). This componentof the antibiotic therapy initially thought to have a lowimmunogenic capacity; however immediate allergic reactionsto CLV have been reported in a 30% of patients allergicto AX-CLV. Basophil activation test (BAT) has shownpromising results demonstrating specific recognition ofCLV determinants. The aim of this study was to assess thevalue of BAT in the evaluation of immediate allergic reactionsto CLV.MethodPatients with a strong clinical history of having sufferedan immediate reaction after AX-CLV administrationwere evaluated. The allergological study followed theEuropean Academy guidelines, included skin test withpenicillin G, AX, and CLV determinants and drug provocationtest when indicated. BAT was carried out usingAX and CLV at different concentrations (2.5, 1.25, 0.25and 0.05 mg/ml).ResultsAmong 75 patients included, 64 were finally diagnosed asallergic, 26 to AX and 38 to CLV. The sensitivity of BATwas 60% and the specificity 81.8%. The inclusion of AXdeterminant produced a BAT sensitivity of 54.1% whereasCLV determinant produced a BAT sensitivity of 78.6%with a specificity of 91% and 82% respectively. In patientsdiagnosed as allergic to AX the BAT sensitivity was 50%whereas in patients allergic to CLV, BAT sensitivity was65.8%.ConclusionThe inclusion of clavulanic acid in the basophil activationtest increases its diagnostic capacity in patients withimmediate allergic reaction to the combination amoxicillinclavulanicacid.
机译：背景技术克拉维酸（CLV）如今经常包含在用阿莫西林（AX）治疗中。最初认为抗生素治疗的这一成分具有较低的免疫原性。但是，已有30％的AX-CLV过敏患者报告了对CLV的立即过敏反应。嗜碱性粒细胞活化试验（BAT）已显示出有希望的结果，证明了对CLV决定簇的特异性识别。这项研究的目的是评估BAT在评估对CLV的立即过敏反应中的价值。方法对临床病史丰富且在AX-CLV给药后立即发生反应的患者进行评估。变应性研究遵循了欧洲研究院的指导原则，包括皮肤试验，青霉素G，AX和CLV决定因素以及药物激发试验。分别使用浓度分别为2.5、1.25、0.25和0.05 mg / ml的AX和CLV进行BAT。结果包括75例患者，其中64例最终被诊断为变态反应，其中26例为AX，38例为CLV。 BAT的敏感性为60％，特异性为81.8％。包含AX决定簇产生的BAT敏感性为54.1％，而CLV决定簇产生的BAT敏感性为78.6％，特异性分别为91％和82％。诊断为AX过敏的患者的BAT敏感性为50％，而对CLV过敏的患者的BAT敏感性为65.8％。结论嗜碱性粒细胞活化试验中加入了克拉维酸可提高对阿莫西林-克拉维酸联合过敏反应的患者的诊断能力。

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