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首页> 外文期刊>Clinical and Translational Allergy >Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA 2 LEN study
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Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA 2 LEN study

机译：鼻吸气流量峰值作为过敏原暴露室激发研究的结果：GA 2 LEN研究

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Background The GA2LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs. Methods In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the GA2LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30?min during a challenge using a portable PNIF meter. Results 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p Conclusion PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC.
机译：背景技术GA 2 LEN腔室已被开发为一种新型的移动性变应原暴露腔室（AEC），可以进行标准化的多中心过敏试验。迄今为止，主观的鼻部症状评分是最常用的结果参数，但是在标准化的现代试验中，客观参数是首选。尽管具有实用性，但客观参数峰值吸鼻流量（PNIF）在过敏原暴露室设置中很少用于过敏试验。本研究旨在评估PNIF作为AEC激发研究的结果参数。方法在随机控制的致盲性鼻炎患者中，在GA 2 LEN室中将其暴露于草花粉，桦树花粉，屋尘螨和/或安慰剂中。使用不同的过敏原浓度来评估症状严重程度。病人在进行挑战之前和之后每30分钟必须使用便携式PNIF测量仪进行PNIF。结果86名受试者共参加了203个挑战。屋内尘螨的激怒导致PNIF值下降幅度最大，其次是草粉和桦木花粉。每种变应原或花粉浓度引起的挑衅导致显着减少（p结论PNIF是在AEC中针对变应原特别是草花粉和屋尘螨进行挑衅试验的有用且可行的工具。

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