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首页> 外文期刊>Clinical and Translational Allergy >Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children
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Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children

机译：在腰果致敏儿童中临床相关的开心果和芒果共敏化比例低

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Background Cashew nut, pistachio nut and mango belong to the Anacardiaceae family and are botanically related. Therefore, cashew nut sensitised children are frequently advised to eliminate cashew nuts and pistachio nuts from their diet. The ‘Improvement of Diagnostic mEthods for ALlergy assessment (IDEAL trial number NTR3572) study showed that cashew nut sensitised children were co-sensitised to pistachio nut in 98% of cases and to mango in 21% of cases. The aim of this follow-up study to IDEAL is to assess the clinical relevance of co-sensitisation to pistachio nut and mango in cashew nut sensitised children. Methods Children were recruited from the study: ‘Improvement of Diagnostic mEthods for ALlergy assessment (IDEAL trial number NTR3572). Inclusion criterion for the IDEAL study was sensitization to cashew nut as demonstrated by either SPT or sIgE, and a clinical history of reactions to cashew nuts or no previous (known) exposure. Sensitized children who were tolerant to cashew nuts were excluded. Inclusion criterion for this IDEAL follow-up study was co-sensitization to pistachio nut, regardless the result of the DBPCFC with cashew nut. In this follow-up study a double-blind placebo-controlled food challenge with pistachio nut and an open food challenge with mango were performed. Results Twenty-nine children (mean age of 11.6?years, 62% male) were included. Pistachio nut sensitisation was clinically relevant in only 34% of cashew-sensitised children and only 31% of cashew challenge positive children. None of the children was challenge positive to mango. Conclusion Although co-sensitisation between cashew nut and pistachio nut was observed in 98%, pistachio nut sensitisation was only clinically relevant in 34% of the children. Therefore, a challenge test with pistachio nut is recommended in children with cashew nut and pistachio nut sensitisation. Trial registration The study was registered in the Dutch trial register (registration number 3572) on 10 August 2012 (retrospectively registered)
机译：背景腰果，开心果和芒果属于漆树科，并且与植物相关。因此，经常建议对腰果敏感的儿童饮食中不要吃腰果和开心果。 ‘用于提高能效的诊断方法的研究（IDEAL试验编号NTR3572）研究表明，对腰果敏感的儿童对开心果和芒果对芒果的共同致敏性分别为98％和21％。这项对IDEAL的后续研究的目的是评估腰果致敏儿童对开心果和芒果的共同致敏作用的临床相关性。方法从研究中招募儿童：“改进诊断方法以进行能谱评估（IDEAL试验编号NTR3572）。 IDEAL研究的纳入标准是通过SPT或sIgE证明对腰果过敏，以及对腰果反应的临床病史或以前没有（已知）暴露。耐受腰果的过敏儿童被排除在外。此IDEAL后续研究的纳入标准是对开心果的共敏化作用，无论DBPCFC与腰果的结果如何。在这项后续研究中，进行了使用开心果的双盲安慰剂对照食品试验和使用芒果的开放食品试验。结果纳入29名儿童（平均年龄11.6岁，男性62％）。阿月浑子坚果敏化在腰果致敏儿童中仅占34％，在腰果挑战阳性儿童中仅占31％。没有一个孩子对芒果有积极的挑战。结论尽管在98％的儿童中观察到腰果和开心果之间存在共同致敏作用，但开心果致敏性仅在34％的儿童中具有临床意义。因此，对于腰果和开心果过敏的儿童，建议使用开心果进行挑战试验。试验注册该研究已于2012年8月10日在荷兰试验注册簿中注册（注册号3572）（已追溯注册）。

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