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首页> 外文期刊>Clinical and Translational Allergy >Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis
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Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis

机译：从童年到成年，过敏性鼻炎和合并症哮喘的患病率是否发生性别变化？荟萃分析

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Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specific differences in the prevalence of coexisting allergic rhinitis and asthma in childhood, adolescence and adulthood. Post-hoc analysis of systematic review with meta-analysis concerning sex-specific prevalence of allergic rhinitis. Using random-effects meta-analysis, we assessed male–female ratios for coexisting allergic rhinitis and asthma in children (0–10?years), adolescents (11–17) and adults (>?17). Electronic searches were performed using MEDLINE and EMBASE for the time period 2000–2014. We included population-based observational studies, reporting coexisting allergic rhinitis and asthma as outcome stratified by sex. We excluded non-original or non-population-based studies, studies with only male or female participants or selective patient collectives. From a total of 6539 citations, 10 studies with a total of 93,483 participants met the inclusion criteria. The male–female ratios (95% CI) for coexisting allergic rhinitis and asthma were 1.65 (1.52; 1.78) in children (N?=?6 studies), 0.61 (0.51; 0.72) in adolescents (N?=?2) and 1.03 (0.79; 1.35) in adults (N?=?2). Male–female ratios for allergic rhinitis only were 1.25 (1.19; 1.32, N?=?5) in children, 0.80 (0.71; 0.89, N?=?2) in adolescents and 0.98 (0.74; 1.30, N?=?2) in adults, respectively. The prevalence of coexisting allergic rhinitis and asthma shows a clear male predominance in childhood and seems to switch to a female predominance in adolescents. This switch was less pronounced for allergic rhinitis only.
机译：变应性鼻炎和哮喘作为一个单一的个体，在儿童时期对男孩的影响大于对女孩的影响，但在成年期对女性的影响更大。但是，尚不清楚这种流行性变迁是否也发生在变应性鼻炎和并发哮喘中。因此，我们的目的是比较儿童，青少年和成年期并存的变应性鼻炎和哮喘患病率的性别差异。事后分析的系统回顾与变态反应性鼻炎的性别特定患病率的荟萃分析。使用随机效应荟萃分析，我们评估了儿童（0-10岁），青少年（11-17岁）和成人（> 17岁）并存的变应性鼻炎和哮喘的男女比例。在2000-2014年期间，使用MEDLINE和EMBASE进行了电子搜索。我们纳入了基于人群的观察性研究，报告了并存的过敏性鼻炎和哮喘是按性别分层的结局。我们排除了非原始或基于非人群的研究，仅针对男性或女性参与者或选择性患者集体的研究。在总共6539次引用中，有93,483名参与者的10项研究符合纳入标准。并存的变应性鼻炎和哮喘的男女比例（95％CI）为儿童（N≥6研究）为1.65（1.52; 1.78），青少年（N≥2）为0.61（0.51; 0.72），成人（N≥2）为1.03（0.79; 1.35）。儿童变态反应性鼻炎的男女比例仅为1.25（1.19; 1.32，N？=？5），青少年为0.80（0.71; 0.89，N？=？2）和0.98（0.74; 1.30，N？=？2 ）。变应性鼻炎和哮喘并存的患病率在儿童期显示出明显的男性优势，而在青少年时期似乎转向了女性优势。仅对于变应性鼻炎，这种改变不太明显。

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