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Inflammation, Atherosclerosis, and Coronary Artery Disease: PET/CT for the Evaluation of Atherosclerosis and Inflammation

机译:炎症,动脉粥样硬化和冠状动脉疾病:PET / CT用于评估动脉粥样硬化和炎症

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Atherosclerosis is a prevalent cardiovascular disease marked by inflammation and the formation of plaque within arterial walls. As the disease progresses, there is an increased risk of major cardiovascular events. Owing to the nature of atherosclerosis, it is imperative to develop methods to further understand the physiological implications and progression of the disease. The combination of positron emission tomography (PET)/computed tomography (CT) has proven to be promising for the evaluation of atherosclerotic plaques and inflammation within the vessel walls. The utilization of the radiopharmaceutical tracer, 18F-fluorodeoxyglucose (18F-FDG), with PET/CT is invaluable in understanding the pathophysiological state involved in atherosclerosis. In this review, we will discuss the use of 18F-FDG-PET/CT imaging for the evaluation of atherosclerosis and inflammation both in preclinical and clinical studies. The potential of more specific novel tracers will be discussed. Finally, we will touch on the potential benefits of using the newly introduced combined PET/magnetic resonance imaging (MRI) for non-invasive imaging of atherosclerosis.
机译:动脉粥样硬化是一种常见的心血管疾病,其特征在于炎症和动脉壁内斑块的形成。随着疾病的进展,发生重大心血管事件的风险增加。由于动脉粥样硬化的性质,必须开发进一步了解疾病的生理学意义和进展的方法。事实证明,正电子发射断层扫描(PET)/计算机断层扫描(CT)的结合有望用于评估动脉粥样硬化斑块和血管壁内的炎症。放射性药物示踪剂18F-氟脱氧葡萄糖(18F-FDG)与PET / CT的结合在理解动脉粥样硬化的病理生理状态方面具有不可估量的价值。在这篇综述中,我们将讨论在临床前和临床研究中使用18F-FDG-PET / CT成像评估动脉粥样硬化和炎症。将讨论更具体的新型示踪剂的潜力。最后,我们将探讨使用新引入的PET /磁共振成像(MRI)进行动脉粥样硬化非侵入性成像的潜在好处。

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