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首页> 外文期刊>Clinical kidney journal. >Recurrence of ANCA-negative renal-limited pauci-immune glomerulonephritis in the renal allograft
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Recurrence of ANCA-negative renal-limited pauci-immune glomerulonephritis in the renal allograft

机译：肾同种异体移植中ANCA阴性的肾功能受限的弱免疫性肾小球肾炎的复发

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摘要

Renal transplantation is the treatment of choice for end-stage renal disease (ESRD) due to pauci-immune crescentic glomerulonephritis (PICGN). A small subgroup of patients with PICGN are anti-neutrophil cytoplasmic antibody (ANCA) negative. We report a case of a patient with ANCA-negative renal-limited form of PICGN who developed ESRD despite treatment. He underwent live-related renal allograft transplantation after 12 months on haemodialysis. In the eighth post-transplant month, he developed graft dysfunction, which on evaluation turned out to be a graft recurrence of the basic disease in the form of PICGN. He received treatment with methylprednisolone, cyclophosphamide and plasmapheresis. However, his renal functions did not improve and he developed graft loss in the 11th post-transplant month and was started on continuous ambulatory peritoneal dialysis. We report a rare recurrence of renal-limited PICGN in the allograft. Patients with PICGN undergoing renal transplantation should be followed up carefully, and an early biopsy should be performed in the case of graft dysfunction to deal with this potentially graft-threatening complication.
机译：肾移植是由于弱免疫性新月形肾小球肾炎（PICGN）而导致的终末期肾脏疾病（ESRD）的治疗选择。 PICGN患者的一小部分患者抗中性粒细胞胞浆抗体（ANCA）阴性。我们报道一例PICNA的ANCA阴性肾限制型PICGN患者，尽管经过治疗但仍发展为ESRD。血液透析12个月后，他接受了与生活相关的同种异体肾移植。在移植后的第八个月，他患上了移植物功能障碍，经评估证明是PICGN形式的基本疾病的移植物复发。他接受了甲泼尼龙，环磷酰胺和血浆置换术的治疗。但是，他的肾功能没有改善，并且在移植后第11个月出现了移植物丢失，并开始进行非卧床腹膜透析。我们报道了同种异体肾移植中肾功能受限的PICGN罕见复发。接受肾移植的PICGN患者应仔细随访，如果移植物功能异常，应尽早进行活检以应对这种潜在的威胁移植物的并发症。

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