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首页> 外文期刊>Clinical kidney journal. >The development of membranous lupus nephritis during treatment with mycophenolate mofetil for proliferative renal disease
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The development of membranous lupus nephritis during treatment with mycophenolate mofetil for proliferative renal disease

机译：霉酚酸酯治疗增生性肾脏疾病期间膜性狼疮肾炎的发展

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The transformation of lupus nephritis from one histologic pattern to another is well described. We report a case of a patient who initially presented with diffuse proliferative glomerulonephritis and was treated with prednisone and mycophenolate mofetil (MMF). She initially responded well to therapy, but later developed high-grade proteinuria while still on MMF and low-dose steroids. A repeat biopsy performed after the increase in proteinuria demonstrated that she had focal proliferative disease but that she had also developed membranous lupus nephritis. Our case is unique in that we report a patient who developed membranous lupus nephritis while receiving MMF.
机译：狼疮性肾炎从一种组织学模式转变为另一种组织学模式已得到充分描述。我们报告一例患者最初出现弥漫性增生性肾小球肾炎，并接受泼尼松和霉酚酸酯（MMF）治疗。她最初对治疗反应良好，但后来在仍服用MMF和低剂量类固醇的情况下发展为高蛋白尿。蛋白尿增加后再次进行活检表明她患有局灶性增生性疾病，但也发展了膜性狼疮性肾炎。我们的病例是独特的，因为我们报告了一名患者在接受MMF时发生了膜性狼疮性肾炎。

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