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An unusual renal manifestation of chronic HBV infection

机译:慢性HBV感染的异常肾脏表现

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Hepatitis B viral infection is usually a self-limiting disease in immunocompetent individuals. Chronic infection can be seen in up to 5% of infected patients. Renal manifestations of chronic HBV infection are usually glomerular. We describe here an uncommon presentation of a patient with chronic HBV infection with very high viral load and rapidly progressive renal failure. Renal biopsy showed features of tubulointerstitial nephritis and tubular epithelial inclusion bodies suggestive of HBV infection. Entecavir treatment slowed down the progression of his renal disease. Tubulointerstitial nephritis should be considered as a part of the differential diagnosis in patients with HBV infection. Early antiviral treatment may halt the progression of renal disease.
机译:乙肝病毒感染通常是具有免疫能力的个体的自限性疾病。多达5%的感染患者可见慢性感染。慢性HBV感染的肾脏表现通常是肾小球。我们在这里描述了一种具有非常高的病毒载量和迅速进行性肾衰竭的慢性HBV感染患者的罕见表现。肾活检显示肾小管间质性肾炎和肾小管上皮包涵体,提示乙肝病毒感染。恩替卡韦治疗减慢了他的肾脏疾病的进展。小管间质性肾炎应被视为HBV感染患者鉴别诊断的一部分。早期抗病毒治疗可能会阻止肾脏疾病的进展。

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