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首页> 外文期刊>Clinical kidney journal. >Fasting during the month of Ramadan among patients with chronic kidney disease: renal and cardiovascular outcomes
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Fasting during the month of Ramadan among patients with chronic kidney disease: renal and cardiovascular outcomes

机译：患有慢性肾脏疾病的患者在斋月期间的禁食：肾脏和心血管疾病的结局

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Background Fasting during the month of Ramadan is a religious obligation for Muslims who represent 20% of the world population. This study explores the safety of fasting for a whole month among patients with chronic kidney disease (CKD) with the possible risk of dehydration and hyperviscosity leading to deterioration of kidney functions and vascular thrombosis. Methods We followed CKD patients with stable kidney function who chose to fast during the month of Ramadan. A group of nonfasting CKD patients served as controls. Serum creatinine was recorded at the beginning of the month, after 1 week of fasting, at the end of the month and 3 months later. Patients were followed for major adverse cardiovascular events (MACE). Results A total of 131 CKD patients were recruited and included in two groups: fasting and nonfasting (mean baseline estimated glomerular filtration rate 27.7, SD 13 and 21.5, SD 11.8 mL/min/1.73 m2, respectively). A rise of serum creatinine was noted during fasting in 60.4% of patients by Day 7 and was associated with intake of renin angiotensin aldosterone system antagonists [relative risk (RR) 2, P = 0.002]. Adverse cardiovascular events were observed in six patients in the fasting cohort and were associated with a rise of serum creatinine after 1 week of fasting (P = 0.009) and the presence of pre-existing cardiovascular disease (RR 15, P = 0.001); the latter association was confirmed by logistic regression analysis. Only one event was recorded in the nonfasting group, P = 0.036. Conclusions MACE occurred more frequently among fasting CKD patients with pre-existing cardiovascular disease and were predicted by an early rise of serum creatinine.
机译：背景斋月期间，斋戒是占世界人口20％的穆斯林的一项宗教义务。这项研究探讨了患有慢性肾脏病（CKD）的患者禁食整月的安全性，可能存在脱水和高粘度导致肾脏功能恶化和血管血栓形成的风险。方法我们追踪了在斋月期间选择禁食的肾功能稳定的CKD患者。一组非空腹CKD患者作为对照。禁食1周后，月末和3个月后的每月初记录血清肌酐。跟踪患者的主要不良心血管事件（MACE）。结果总共招募了131名CKD患者，分为空腹和非空腹两组（平均基线估计肾小球滤过率分别为27.7，SD 13和21.5，SD 11.8 mL / min / 1.73 m 2 ）。到第7天时，禁食期间60.4％的患者血清肌酐升高，并与肾素血管紧张素醛固酮系统拮抗剂的摄入有关[相对危险度（RR）2，P = 0.002]。空腹队列中有6例患者发生了不良心血管事件，与空腹1周后血清肌酐升高相关（P = 0.009）和既往存在心血管疾病（RR 15，P = 0.001）。后一种关联通过逻辑回归分析得到证实。非禁食组仅记录了一个事件，P = 0.036。结论空腹CKD合并心血管疾病的患者中MACE的发生频率更高，并且血清肌酐的升高可预示其发生。

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