...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical Epidemiology >The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project: rationale and planned nationwide studies of genetic predictors, physical exercise, and individualized pharmacological treatment
【24h】

The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project: rationale and planned nationwide studies of genetic predictors, physical exercise, and individualized pharmacological treatment

机译：丹麦2型糖尿病战略研究中心（DD2）项目：遗传预测因子，体育锻炼和个性化药物治疗的基本原理和计划中的全国性研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract: Here we provide an overview of the rationale and methods of a series of planned population based studies within the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project. The project aims to support and evaluate ongoing political and administrative efforts to implement nationwide guidelines for maintaining metabolic control in newly diagnosed type 2 diabetes (T2D) patients to prevent diabetic complications and improve quality of life. The DD2 is designed as a prospective cohort study (collection of epidemiological data) supplemented by randomized clinical intervention trials (on physical exercise and individualized pharmacological treatment) and the establishment of a biobank comprised of material from a large number of newly diagnosed T2D patients. Inclusion of the majority of newly diagnosed T2D patients as they are diagnosed at their general practitioner or diabetes hospital outpatient clinics and entered into the DD2 cohort will establish a nationwide database comprising a large number of future incident cases of T2D in Denmark. These cases will form the project cohort of the DD2. Within the first 6 months of diagnosis, all patients will be invited to contribute to a biobank of DNA, plasma, urine, and tissue sampling. The DNA biobank will enable future studies of the effect of pharmacological treatment and outcome in subsets of patients with specific genetic risk profiles covering disease etiology and specific drug kinetics and metabolism. We will also perform two clinical intervention trials examining: the effectiveness of physical exercise on diabetes-related outcomes and the impact of trial outcomes on individualized pharmacological treatment. Moreover, the DD2 will serve as a platform for testing and developing new antidiabetic drugs. All together, we expect this study to contribute to substantially improved diabetes care in T2D patients locally and abroad.
机译：摘要：这里我们概述了丹麦2型糖尿病战略研究中心（DD2）项目中一系列基于人群的计划研究的基本原理和方法。该项目旨在支持和评估正在进行的政治和行政工作，以实施全国性指南，以维持新诊断的2型糖尿病（T2D）患者的代谢控制，从而预防糖尿病并发症并改善生活质量。 DD2被设计为一项前瞻性队列研究（流行病学数据的收集），并辅以随机临床干预试验（体育锻炼和个体化药理治疗），并建立了由大量新诊断的T2D患者材料组成的生物库。包括在普通科医生或糖尿病医院的门诊诊所被诊断出并进入DD2队列的大多数新诊断的T2D患者，将建立一个全国性的数据库，其中包括丹麦未来大量的T2D事件。这些案例将构成DD2的项目队列。在诊断的前6个月内，将邀请所有患者参与DNA，血浆，尿液和组织采样的生物样本库。 DNA生物库将使未来对药理学治疗效果和结局的研究成为可能，这些患者具有特定的遗传风险特征，涵盖疾病病因，特定的药物动力学和代谢。我们还将进行两项临床干预试验，以检查：体育锻炼对糖尿病相关结局的有效性以及试验结局对个体药物治疗的影响。此外，DD2将作为测试和开发新的抗糖尿病药物的平台。总之，我们希望这项研究能够为当地和国外的T2D患者大大改善糖尿病护理做出贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号