...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical kidney journal. >Nodular glomerulosclerosis with anti-glomerular basement membrane-like glomerulonephritis; a distinct pattern of kidney injury observed in smokers
【24h】

Nodular glomerulosclerosis with anti-glomerular basement membrane-like glomerulonephritis; a distinct pattern of kidney injury observed in smokers

机译：结节性肾小球硬化症伴肾小球基底膜样肾小球肾炎;在吸烟者中观察到明显的肾脏损伤

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Cigarette smoking has recently been recognized as a risk factor for developing nodular glomerulosclerosis and has also been frequently encountered in patients with anti-glomerular basement membrane (anti-GBM) disease. However, the concurrent presence of both patterns of glomerular injury has not been previously reported. Material and methods In this article, we describe three patients with non-diabetic nodular glomerulosclerosis, anti-GBM-like glomerulonephritis (GN) and a history of heavy smoking. Results Our cohort included three patients, of which two were men (53 and 77 years old) and one a 28-year-old woman. None of the patients had a history of diabetes mellitus but all of them were heavy smokers who presented with renal insufficiency and proteinuria. Nodular glomerulosclerosis and occasional small, non-circumferential crescents in different stages of development were found on kidney biopsy. Immunofluorescence microscopy studies showed intense linear IgG staining along the glomerular basement membranes in the absence of granular immune-type deposits. Electron microscopy evaluation revealed prominent endothelial cell injury without detectable electron-dense deposits. One patient was dialysis-dependent a few months post-biopsy while the other two patients maintained their kidney function 18 and 24 months post-biopsy but without a significant improvement of serum creatinine. Conclusions The combination of nodular glomerulosclerosis and anti-GBM-like GN appears to be a distinct pattern of injury observed in a small subset of heavy smokers. Although this pattern of glomerular injury might be less aggressive than the typical anti-GBM GN, it does not appear to carry a favorable prognosis.
机译：背景技术最近，吸烟被认为是发展结节性肾小球硬化的危险因素，并且在患有抗肾小球基底膜（anti-glomerular base film，anti-GBM）疾病的患者中也经常遇到。然而，先前尚未报道过两种肾小球损伤同时存在。材料和方法在本文中，我们描述了三例非糖尿病性结节性肾小球硬化症，抗GBM样肾小球肾炎（GN）和重度吸烟史。结果我们的队列包括3例患者，其中2例为男性（53岁和77岁），另一例为28岁的女性。所有患者均无糖尿病史，但均为重度吸烟者，表现为肾功能不全和蛋白尿。肾脏活检发现在不同发育阶段的结节性肾小球硬化和偶发的小，非环周新月。免疫荧光显微镜研究表明，在没有颗粒免疫型沉积物的情况下，沿肾小球基底膜呈强烈的线性IgG染色。电子显微镜评估显示内皮细胞明显受损，没有可检测到的电子致密沉积物。一名患者在活检后几个月依赖透析，而其他两名患者在活检后18和24个月保持肾脏功能，但血清肌酐没有明显改善。结论结节性肾小球硬化和抗GBM样GN的结合似乎是一小部分重度吸烟者中观察到的独特损伤模式。尽管这种肾小球损伤的模式可能不如典型的抗GBM GN更具侵略性，但似乎未预示良好的预后。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号