Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer

Yue Hu; Mingrui Dai; Yayuan Zheng; Jiaxin Wu; Bin Yu; Haihong Zhang; Wei Kong; Hui Wu; Xianghui Yu

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Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer

机译：Snail2对结直肠癌转移过程中E-cadherin表达的表观遗传抑制

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BackgroundThe transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown.

机译：背景转录因子Snail2是致癌过程中E-钙粘蛋白表达的阻遏物;然而，人类结直肠癌（CRC）的这一过程涉及的具体机制仍然未知。

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《Clinical epigenetics.》 |2018年第1期|共页
作者
Yue Hu; Mingrui Dai; Yayuan Zheng; Jiaxin Wu; Bin Yu; Haihong Zhang; Wei Kong; Hui Wu; Xianghui Yu;
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中图分类临床医学;
关键词
Colorectal cancerSnail2E-cadherinMetastasisEZH2HDAC6;

机译：大肠癌Snail2E-钙粘着蛋白转移EZH2HDAC6;

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专利

1. EZH2-mediated epigenetic suppression of EphB3 inhibits gastric cancer proliferation and metastasis by affecting E-cadherin and vimentin expression [J] . Zhao Kun, He Jing, Wang Yan-fen, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2019,第期

机译：EzH2介导的EphB3的表观抑制抑制胃癌增殖和转移通过影响E-cadherin和Vimentin表达来抑制胃癌增殖和转移
2. Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs [J] . Yue Hu, Yayuan Zheng, Mingrui Dai, Cell adhesion & migration . 2019,第1期

机译：Snail2诱导的G9a和HDAC促进肺癌中E-钙黏着蛋白的抑制和转移
3. CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin [J] . Jingjing Xu, Jun Zhou, Hanjue Dai, Journal of Translational Medicine . 2018,第1期

机译：通过通过MAPK和AKT信号传导和抑制E-Cadherin来促进结肠直肠癌转移作为癌基因的芯片用作癌基因。
4. Expression and clinical significance of E-cadherin and MMP-2 in human colorectal carcinoma [C] . Minna Gao, Bo Zeng International Conference on Human Health and Medical Engineering. . 2014

机译：e-cadherin和MMP-2在人结肠直肠癌中的表达及临床意义
5. Analysis of somatic mutations identified by whole-exome sequencing in colorectal cancer metastasis [D] . Zhao, Bixiao 2016

机译：通过全外显子测序鉴定的大肠癌转移中的体细胞突变分析
6. Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer [O] . Yue Hu, Mingrui Dai, Yayuan Zheng, 2018

机译：Snail2在结直肠癌转移过程中表观遗传抑制E-cadherin表达
7. TCF12 protein functions as transcriptional repressor of E-cadherin, and its overexpression is correlated with metastasis of colorectal cancer [O] . Lee, CC 2012

机译：TCF12蛋白作为E-cadherin的转录阻遏物，其过表达与结直肠癌的转移有关

Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer

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