Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer

Hidenori Hidaka; Ken Higashimoto; Saori Aoki; Hiroyuki Mishima; Chisa Hayashida; Toshiyuki Maeda; Yasuo Koga; Hitomi Yatsuki; Keiichiro Joh; Hirokazu Noshiro; Ryuichi Iwakiri; Atsushi Kawaguchi; Koh-ichiro Yoshiura; Kazuma Fujimoto; Hidenobu Soejima

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Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer

机译：大肠癌印迹相关差异甲基化区域的全面甲基化分析

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BackgroundImprinted genes are regulated by DNA methylation at imprinting-associated differentially methylated regions (iDMRs). Abnormal expression of imprinted genes is implicated in imprinting disorders and tumors. In colorectal cancer (CRC), methylation and imprinting status of the IGF2/H19 domain have been studied. However, no comprehensive methylation analysis of iDMRs in CRC has been reported. Furthermore, the relationship between iDMR methylation status and other methylation-related issues, such as CpG island methylator phenotype (CIMP) and long interspersed element-1 (LINE-1) methylation, remains unclear.

机译：背景印迹基因在印迹相关的差异甲基化区域（iDMR）受DNA甲基化调控。印记基因的异常表达与印记障碍和肿瘤有关。在结直肠癌（CRC）中，已经研究了IGF2 / H19域的甲基化和印迹状态。但是，尚未报道CRC中iDMR的全面甲基化分析。此外，iDMR甲基化状态与其他甲基化相关问题（例如CpG岛甲基化子表型（CIMP）和长时间散布的element-1（LINE-1）甲基化）之间的关系仍不清楚。

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《Clinical epigenetics.》 |2018年第1期|共页
作者
Hidenori Hidaka; Ken Higashimoto; Saori Aoki; Hiroyuki Mishima; Chisa Hayashida; Toshiyuki Maeda; Yasuo Koga; Hitomi Yatsuki; Keiichiro Joh; Hirokazu Noshiro; Ryuichi Iwakiri; Atsushi Kawaguchi; Koh-ichiro Yoshiura; Kazuma Fujimoto; Hidenobu Soejima;
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中图分类临床医学;
关键词
Genomic imprintingDNA methylationiDMRCIMPBRAF mutationKRAS mutationLINE-1IGF2-DMR0IGF2 LOI;

机译：基因组印迹DNA甲基化iDMRCIMPBRAF突变KRAS突变LINE-1IGF2-DMR0IGF2 LOI;

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1. Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations [J] . Maeda Toshiyuki, Higashimoto Ken, Jozaki Kosuke, Genetics in medicine . 2014,第Pta12期

机译：全面和定量的多基因座甲基化分析显示，在伴有突变的Beckwith-Wiedemann综合征中，特定印迹差异化甲基化区域对异常甲基化的敏感性
2. Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region [J] . NishiharaR., WangM., QianZ.R., The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition . 2014,第6期

机译：根据IGF2甲基化差异区域的甲基化水平，酒精，一碳营养摄入量和大肠癌风险
3. Identification of lung cancer specific differentially methylated regions using genome-wide DNA methylation study [J] . Yoonki Hong, Seok-Ho Hong, Yeon-Mok Oh, Molecular & Cellular Toxicology . 2018,第3期

机译：使用全基因组DNA甲基化研究鉴定肺癌特异性差异甲基化区域
4. Differential Analysis of Proteins from Caveolin-Rich Lipid Rafts in Primary and Metastatic Colorectal Cancer Clones [C] . Shirley S. Arielly, Matty Ariel, Rivka Yehuda, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：富含富含肝素的脂肪筏中蛋白质的差异分析，转移性结直肠癌克隆
5. Bayesian Functional Data Analysis Over Dependent Regions and Its Application for Identification of Differentially Methylated Regions [D] . Chatterjee, Suvo. 2019

机译：贝叶斯函数数据分析与依赖区域及其鉴定差异甲基化区域的应用
6. Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer [O] . Hidenori Hidaka, Ken Higashimoto, Saori Aoki, 2018

机译：大肠癌印迹相关差异甲基化区域的全面甲基化分析
7. Comprehensive high throughput array–based methylation analysis to identify variably methylated regions (VMRs) associated with disease risks [O] . 2010

机译：综合高通量阵列的甲基化分析，以鉴定与疾病风险相关的可变甲基化地区（VMRS）

Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer

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