...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical, Cosmetic and Investigational Dermatology >Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (NAE-8?)
【24h】

Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (NAE-8?)

机译：夹竹桃叶（NAE-8？）的芦荟提取物的抗氧化，抗炎，抗凋亡和皮肤再生特性。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: The goal for this study was to evaluate the effects of an Aloe vera-based Nerium oleander extract (NAE-8?), compared to an extract of A. vera gel alone (ALOE), and to an aqueous extract of N. oleander (AQ-NOE) in bioassays pertaining to dermatologic potential with respect to antioxidant protection, anti-inflammatory effects, and cytokine profiles in vitro. Methods: Cellular antioxidant protection was evaluated in three separate bioassays: The cellular antioxidant protection of erythrocytes (CAP-e) assay, protection of cellular viability and prevention of apoptosis, and protection of intracellular reduced glutathione levels, where the last two assays were performed using human primary dermal fibroblasts. Reduction of intracellular formation of reactive oxygen species (ROS) was tested using polymorphonuclear cells in the absence and presence of oxidative stress. Changes to cytokine and chemokine profiles when whole blood cells and human primary dermal fibroblasts were exposed to test products were determined using a 40-plex Luminex array as a method for exploring the potential cross-talk between circulating and skin-resident cells. Results: The NAE-8? provided significantly better antioxidant protection in the CAP-e bioassay than AQ-NOE. NAE-8? and AQ-NOE both protected cellular viability and intracellular reduced glutathione, and reduced the ROS formation significantly when compared to control cells, both under inflamed and neutral culture conditions. ALOE showed minimal effect in these bioassays. In contrast to the NAE-8?, the AQ-NOE showed induction of inflammation in the whole blood cultures, as evidenced by the high induction of CD69 expression and secretion of a number of inflammatory cytokines. The treatment of dermal fibroblasts with NAE-8? resulted in selective secretion of cytokines involved in collagen and hyaluronan production as well as re-epithelialization during wound healing. Conclusion: NAE-8?, a novel component of a commercial cosmetic product, showed beneficial antioxidant protection in several cellular models, without the induction of leukocyte activation and secretion of inflammatory cytokines. The biological efficacy of NAE-8? was unique from both ALOE and AQ-NOE.
机译：目的：这项研究的目的是评估与单独的芦荟凝胶提取物（ALOE）和N.的水提取物相比，基于芦荟的夹竹桃夹竹桃提取物（NAE-8？）的作用。生物测定中的夹竹桃（AQ-NOE），涉及体外抗氧化保护，抗炎作用和细胞因子特性方面的皮肤病学潜力。方法：在三种单独的生物测定中评估了细胞的抗氧化保护作用：红细胞的细胞抗氧化保护（CAP-e）测定，细胞活力的保护和细胞凋亡的预防以及细胞内还原型谷胱甘肽水平的保护，其中最后两项测定使用人原代皮肤成纤维细胞。在不存在和存在氧化应激的情况下，使用多形核细胞测试了活性氧（ROS）在细胞内形成的减少。使用40重Luminex阵列确定全血细胞和人类原代皮肤成纤维细胞暴露于测试产品时细胞因子和趋化因子谱的变化，作为探索循环细胞与皮肤驻留细胞之间潜在串扰的方法。结果：NAE-8？与AQ-NOE相比，在CAP-e生物测定中提供了明显更好的抗氧化保护。 NAE-8？与对照细胞相比，AQ-NOE和AQ-NOE在发炎和中性培养条件下均能保护细胞活力和减少细胞内的谷胱甘肽，并显着减少ROS的形成。在这些生物测定中，ALOE的作用很小。与NAE-8α相反，AQ-NOE在全血培养物中显示出炎症的诱导，这由CD69表达的高诱导和许多炎性细胞因子的分泌证明。用NAE-8治疗皮肤成纤维细胞？导致伤口愈合过程中胶原和透明质酸产生中涉及的细胞因子的选择性分泌以及上皮再形成。结论：NAE-8？是一种商业化妆品的新型成分，在几种细胞模型中均显示出有益的抗氧化保护作用，而没有诱导白细胞活化和炎性细胞因子的分泌。 NAE-8的生物学功效？在ALOE和AQ-NOE中都是独一无二的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号