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首页> 外文期刊>Clinical, Cosmetic and Investigational Dermatology >New approach to the understanding of keloid: psychoneuroimmune–endocrine aspects
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New approach to the understanding of keloid: psychoneuroimmune–endocrine aspects

机译：理解瘢痕understanding的新方法：心理神经免疫-内分泌方面

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Abstract: The skin is a dynamic and complex organ that relies on the interrelation among different cell types, macromolecules, and signaling pathways. Further, the skin has interactions with its own appendages and other organs such as the sebaceous glands and hair follicles, the kidney, and adrenal glands; systems such as the central nervous system; and axes such as the hypothalamic–pituitary–adrenal axis. These continuous connections give the skin its versatility, and when an injury is caused, some triggers start a cascade of events designed to restore its integrity. Nowadays, it is known that this psychoneuroimmune–endocrine intercommunication modulates both the homeostatic condition and the healing process. In this sense, the skin conditions before a trauma, whether of endogenous (acne) or exogenous origin (injury or surgical incision), could regulate the process of tissue repair. Most skin diseases such as psoriasis and atopic dermatitis, among others, have in their pathophysiology a psychogenic component that triggers integrated actions in the nervous, immune, and endocrine systems. However, fibroproliferative disorders of wound healing, such as hypertrophic scar and keloid, are not yet included in this listing, despite showing correlation with stress, especially with the psychosocial character. This review, by understanding the "brain–skin connection", presents evidence that allows us to understand the keloid as a psychomediated disease.
机译：摘要：皮肤是一个动态而复杂的器官，它依赖于不同细胞类型，大分子和信号通路之间的相互关系。此外，皮肤与其自身的附件和其他器官（如皮脂腺和毛囊，肾脏和肾上腺）相互作用。中枢神经系统等系统;以及下丘脑-垂体-肾上腺轴等轴。这些连续的连接使皮肤具有多功能性，当造成伤害时，一些触发器会触发一系列旨在恢复其完整性的事件。如今，众所周知，这种心理神经免疫-内分泌互通可以调节稳态条件和愈合过程。从这个意义上说，外伤之前的皮肤状况，无论是内源性（痤疮）还是外源性（受伤或手术切口），都可以调节组织修复的过程。大多数皮肤病，例如牛皮癣和特应性皮炎，在其病理生理学中都具有引发心理的成分，该成分触发神经，免疫和内分泌系统中的综合作用。但是，伤口愈合的纤维增生性疾病（例如肥厚性瘢痕和瘢痕loid）尚未包括在该清单中，尽管与压力（尤其是心理社会特征）相关。这篇综述通过理解“大脑与皮肤的联系”，提供了证据，使我们能够将瘢痕loid理解为一种心理介导的疾病。

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