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首页> 外文期刊>Clinical ophthalmology >Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy
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Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy

机译：原发性光治疗性角膜切除术后复发性大疱性大疱性角膜病变的复发率和危险因素

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Objective: To assess the recurrent rate, mean survival time, and risk factors associated with recurrent painful bullous keratopathy (BK) after primary treatment with phototherapeutic keratectomy.Methods: Medical records from 72 patients (72 eyes) who had phototherapeutic keratectomy for painful BK were evaluated. Data for sex, age, duration of BK, associated ocular and systemic diseases (hypertension, diabetes mellitus, ischemic heart disease, asthma, dyslipidemia, and rheumatoid arthritis), frequency and degree of pain (grade 1–3), visual acuity, corneal thickness, intraocular pressure, and laser setting were extracted and analyzed.Results: The mean age of the patients was 64.2±11.4 years. The mean preoperative duration of BK was 15.0±11.0 months. Most patients had pseudophakic BK (69.40%). Majority of the cases had grade 3 degree of pain (48.60%). Glaucoma and hypertension were markedly found among these patients (51.40% and 19.40%, respectively). Preoperative mean intraocular pressure and corneal thickness were 13.70±4.95 mmHg and 734.1±83.80 μm, respectively. The mean laser diameter and depth were 8.36±1.22 mm and 38.89±8.81 μm, respectively. Systemic disease was significantly associated with the risk for developing recurrent painful BK (P=0.022, hazard ratio [HR] 1.673, 95% confidence interval [CI] 1.08–2.58). The overall recurrent rate was 51%. The average duration time of recurrent painful BK was 17.3±12.9 months (range 1–50 months). The median survival time before recurrence was 29.0±6.6 months.Conclusion: Systemic disease was found to be the only risk factor significantly associated with the development of recurrent painful BK. Low recurrent rate and long mean survival time showed that phototherapeutic keratectomy was effective in relieving recurrent painful BK and can be used as an alternative procedure for patients waiting for corneal transplantation.
机译：目的：评估光疗性角膜切除术初次治疗后复发性疼痛性大疱性角膜病（BK）的复发率，平均生存时间和危险因素。方法：对72例（72眼）接受光疗性角膜切除术治疗疼痛性BK的患者进行了医疗记录评估。性别，年龄，BK病程，相关的眼和系统疾病（高血压，糖尿病，缺血性心脏病，哮喘，血脂异常和类风湿性关节炎），疼痛的频率和程度（1-3级），视力，角膜的数据结果：患者平均年龄为64.2±11.4岁。 BK的平均术前持续时间为15.0±11.0个月。大多数患者患有假晶状体BK（69.40％）。大多数病例的疼痛等级为3级（48.60％）。在这些患者中，青光眼和高血压明显（分别为51.40％和19.40％）。术前平均眼压和角膜厚度分别为13.70±4.95 mmHg和734.1±83.80μm。平均激光直径和深度分别为8.36±1.22 mm和38.89±8.81μm。系统性疾病与复发性疼痛性BK的发生风险显着相关（P = 0.022，危险比[HR] 1.673，95％置信区间[CI] 1.08–2.58）。总体复发率为51％。复发性疼痛性BK的平均持续时间为17.3±12.9个月（范围1–50个月）。复发前中位生存时间为29.0±6.6个月。结论：发现全身性疾病是与复发性疼痛性BK的发生显着相关的唯一危险因素。低复发率和长平均生存时间表明，光疗性角膜切除术可有效缓解复发性疼痛性BK，可作为等待角膜移植患者的替代方法。

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