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首页> 外文期刊>Clinical ophthalmology >Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes
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Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes

机译：不同青光眼亚型不对称青光眼严重程度的眼睛的眼球血氧饱和度和血管口径比较

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Background: To compare retinal vessel oxygenation and vessel caliber in primary angle-closure glaucoma (PACG), primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal controls, as well as between eyes of asymmetrical glaucoma severity. Methods: This was a prospective, cross-sectional study. The 159 subjects (PACG, n=39; POAG, n=41; NTG, n=41; normal controls, n=38) underwent retinal oxygen saturation measurements using the Oxymap T1 Retinal Oximeter, optical coherence tomography, and Humphrey visual field testing. Retinal oxygen saturation and vessel diameter were compared between the glaucoma groups and normal controls, as well as between eyes of asymmetrical glaucoma severity. Kruskal–Wallis test was performed for comparison among different subtypes of glaucoma. Wilcoxon signed-rank test was used to compare the inter-eye differences. Results: Compared to normal controls, arteriolar oxygen saturation was increased in PACG eyes ( P =0.048) but not in POAG or NTG eyes. There were no significant differences in oxygen saturation in venules or arteriovenous (AV) difference in all three glaucoma groups. Venular diameter was significantly reduced in all glaucoma groups compared to normal controls ( P <0.001), but no such change was observed in arteriolar diameter ( P =0.10). When comparing between eyes of asymmetrical glaucoma severity, arteriolar oxygen saturation ( P =0.03) and AV difference ( P =0.04) were significantly higher, while arteriolar diameter was significantly lower ( P =0.001) in the worse eye in PACG group. There were no significant differences in oximetric parameters or vessel calibers between the worse and the better eyes in POAG and NTG groups. Conclusion: Eyes with PACG showed increased arteriolar oxygen saturation and increased AV difference. This was not observed in POAG and NTG eyes. Arteriolar diameter in PACG and venular diameter in all three glaucoma groups were reduced. The difference observed in PACG eyes may be due to an increased metabolic demand in the disease process compared to open-angle glaucoma.
机译：背景：为了比较原发性闭角型青光眼（PACG），原发性开角型青光眼（POAG），法向性青光眼（NTG）和正常对照以及非对称性青光眼的严重程度之间的视网膜血管充氧和血管口径。方法：这是一项前瞻性的横断面研究。 159名受试者（PACG，n = 39; POAG，n = 41; NTG，n = 41;正常对照组，n = 38）使用Oxymap T1视网膜血氧仪，光学相干断层扫描和汉弗莱视野测试进行了视网膜氧饱和度测量。比较了青光眼组和正常对照组以及非对称性青光眼严重程度的眼睛之间的视网膜氧饱和度和血管直径。进行Kruskal–Wallis检验以比较青光眼的不同亚型。使用Wilcoxon符号秩检验来比较眼间差异。结果：与正常对照组相比，PACG眼的小动脉血氧饱和度增加（P = 0.048），而POAG或NTG眼则没有。在所有三个青光眼组中，小静脉的氧饱和度或动静脉（AV）差异均无显着性差异。与正常对照组相比，所有青光眼组的静脉直径均显着减小（P <0.001），但小动脉直径未观察到这种变化（P = 0.10）。在不对称青光眼严重程度的两眼之间进行比较时，PACG组中较差眼的小动脉氧饱和度（P = 0.03）和AV差异（P = 0.04）显着较高，而小动脉直径显着较低（P = 0.001）。在POAG和NTG组中，较差和较好的眼睛之间的血氧参数或血管口径没有显着差异。结论：PACG眼显示小动脉血氧饱和度增加和AV差异增加。这在POAG和NTG眼睛中未观察到。在所有三个青光眼组中，PACG的小动脉直径和小静脉直径均减小。与开角型青光眼相比，在PACG眼睛中观察到的差异可能是由于疾病过程中代谢需求增加所致。

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