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首页> 外文期刊>Clinical ophthalmology >In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery
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In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery

机译：过滤手术中使用不同海绵材料的体外丝裂霉素C的吸收和递送

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Purpose: The purpose of this study is to evaluate and compare mitomycin C (MMC) absorption and delivery in different materials used in filtering surgery. Methods: This is an in vitro study comparing polyvinyl alcohol triangular sponges (TS6, TS8), polyvinyl alcohol fluid wicks (EFW), and absorbable gelatin sponges (AGS3, AGS5), from which five different types of transport units were obtained. Seven pieces of sponge of each transport unit type were obtained as follows: two transverse strips were obtained at 6 and 8?mm from the apex of TS and divided into three equal pieces; 4×4?mm pieces of EFW; 3×3 and 5×5?mm pieces of absorbable gelatin sponges were cut. Filter paper was placed on a precision scale (0.01?mg). The seven sponge pieces of each type were weighed three times consecutively in dry and wet states, the latter after immersion for 15?seconds in 0.2?mg/mL MMC. The difference between the weights of the dry and wet filter paper at the end of each measurement sequence was also calculated and considered as an estimate of the amount of mitomycin delivered. Results: The amounts of MMC absorbed by each transport unit were as follows: (mean ± standard deviation) 27.43±5.13 for TS6, 31.91±6.63 for TS8, 15.96±2.23 for EFW, 17.96±2.05 for AGS3, and 33.81±2.05 for AGS5. The amounts of MMC delivered to the filter paper were as follows: 21.70±2.84 for TS6, 23.83±4.03 for TS8, 12.93±1.75 for EFW, 14.69±1.79 for AGS3, and 27.30±1.58 for AGS5. Conclusion: Percentage MMC delivered was similar for all materials, but there was a tendency for greater delivery using larger sponges and greater homogeneity in delivery with AGS5. No statistical differences were found in percentage delivered by the different transport materials.
机译：目的：本研究的目的是评估和比较丝裂霉素C（MMC）在过滤手术中使用的不同材料中的吸收和递送。方法：这是一项体外研究，比较了聚乙烯醇三角海绵（TS6，TS8），聚乙烯醇液芯（EFW）和可吸收明胶海绵（AGS3，AGS5），从中获得了五种不同类型的运输单位。每种运输单元类型的七块海绵按以下方法获得：从TS的顶点分别在6和8？mm处获得两个横向条，并分成三个相等的条; 4×4？mm的EFW;切成3×3和5×5μmm的可吸收明胶海绵。将滤纸放置在精密秤上（0.01？mg）。每种类型的七个海绵片在干燥和湿润状态下连续称重3次，后者在0.2？mg / mL MMC中浸泡15秒后。还计算了每个测量序列结束时干滤纸和湿滤纸的重量之间的差，并将其视为所递送丝裂霉素量的估计值。结果：每个转运单位吸收的MMC量如下：（平均值±标准偏差）TS6为27.43±5.13，TS8为31.91±6.63，EFW为15.96±2.23，AGS3为17.96±2.05，ATW3为33.81±2.05 AGS5。递送到滤纸的MMC的量如下：对于TS6为21.70±2.84，对于TS8为23.83±4.03，对于EFW为12.93±1.75，对于AGS3为14.69±1.79，以及对于AGS5为27.30±1.58。结论：所有材料的MMC交付百分比均相似，但使用更大的海绵有更大的交付趋势，而AGS5的交付具有更高的均质性。不同运输材料的运输百分比没有统计差异。

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