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首页> 外文期刊>Clinical Psychopharmacology and Neuroscience >Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment
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Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment

机译：多奈哌齐治疗改善路易体痴呆中乌鸦彩色渐进矩阵对视空间功能的改善

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摘要

Objective Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil. Methods Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil. Results There were significant improvements of RCPM in the total scores between one year donepezil treatment (p=0.013), in both Set A score (p=0.002) and Set AB score (p=0.015), but trend in the Set B score (p=0.083). Conclusion Donepezil is useful for improving visuo-spatial impairment in DLB, but not for problem-solving impairment.
机译：目的多奈哌齐可改善路易体（DLB）对痴呆的认知障碍。视觉空间功能障碍是DLB的常见症状。非语言Raven的有色渐进矩阵（RCPM）用于评估接受多奈哌齐治疗的DLB受试者的视觉感知和推理能力。方法招募21例DLB患者，平均年龄78.7±4.5岁。在开始多奈哌齐时和开始多奈哌齐后一年内进行RCPM评估。结果一年多奈哌齐治疗之间的总评分（p = 0.013），A组评分（p = 0.002）和AB组评分（p = 0.015）的RCPM都有显着改善，但B组评分（p = 0.015）有趋势。 p = 0.083）。结论多奈哌齐可改善DLB的视觉空间障碍，但不能解决问题。

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