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Visual fields in a chloroquine treatment

机译：氯喹处理的视野

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Purpose: In this study, we describe contrast sensitivity losses in the visual field of a patient affected by chloroquine toxicity, measured with stimuli favoring different visual mechanisms. We have compared these results with those of other, usual clinical tests.Methods: The vision of a patient who underwent ten years of chloroquine treatment was analyzed by a battery of clinical tests: visual acuity (VA), Amsler's grid, Farnsworth–Munsell 100-hue test, spectral domain optical coherence tomography, multifocal electroretinogram (ERG), white-on-white and red-on-white Humphrey perimetries, chromatic and achromatic contrast sensitivity perimetry tests, and fluorescein angiography. Measurements were taken just before the cessation of the treatment, and 6 months later.Results: The subjective visual perception of the patient was worse (in comparison with the rest of the visual field at the time of the first visit) in the center of the visual field, and was impaired on the second visit. Although standard automated perimetry (SAP) was practically normal and ERG results did not worsen with time, VA, Amsler's grid, and visual fields with stimuli favoring the magnocellular and chromatic pathways signalled progressive loss of visual function.Conclusions: Standard tests such as SAP or ERG may not detect visual field losses or progression of existing visual losses in a case of chloroquine toxicity, whereas tests evaluating contrast sensitivity with stimuli favoring different visual mechanisms may be more sensitive.
机译：目的：在这项研究中，我们描述了受氯喹毒性影响的患者视野中对比敏感度的损失，采用有利于不同视觉机制的刺激进行测量。我们将这些结果与其他常规临床测试的结果进行了比较。方法：通过一系列临床测试对经历了十年氯喹治疗的患者的视力进行了分析：视敏度（VA），Amsler网格，Farnsworth–Munsell 100 -色相测试，光谱域光学相干断层扫描，多焦点视网膜电图（ERG），汉弗莱白白相间和红白相像周长，彩色和消色差对比敏感度周长率测试以及荧光素血管造影。结果：在治疗结束前和治疗后6个月进行了测量。结果：患者的主观视觉感觉较差（与第一次就诊时的其余视野相比）。视野，并且在第二次访问时受损。尽管标准自动视野检查（SAP）实际上是正常的，并且ERG结果并未随时间而变差，但VA，Amsler网格和具有刺激性的促进巨细胞和彩色途径的视野表明视觉功能逐渐丧失。结论：标准测试如SAP或在氯喹毒性的情况下，ERG可能无法检测到视野丧失或现有视觉丧失的进展，而评估对比敏感度并采用有利于不同视觉机制的刺激的测试可能更为敏感。

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