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首页> 外文期刊>Clinical Medicine: Gastroenterology >Underlying—Disease Risk for Antispasmodic Premedication in Older Patients Undergoing Investigations of the Gastrointestinal Tract
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Underlying—Disease Risk for Antispasmodic Premedication in Older Patients Undergoing Investigations of the Gastrointestinal Tract

机译：正在进行胃肠道研究的老年患者进行解痉镇痛的潜在疾病风险

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Purpose: Improve risk management of patients undergoing investigations of the gastrointestinal (GI) tract, in regard to underlying diseases and choice of premedication. According to a nationwide survey in Japan, 74% of the deaths associated with premedication were patients aged 60 years or over. Methods: Subjects were 418 patients undergoing investigations of the GI tract (367 endoscopy, 51 barium contrast radiography) between October 2001 and January 2004. Age distribution peaked in the 65-69 years group, and 40% of subjects were aged 65 years and over. Using a questionnaire, each subject was interviewed prior to the investigation to determine contraindications for anticholinergic agents or glucagon preparations. To confirm the risk associated with antispasmodic agents in elderly subjects, the group was subdivided into those aged under 65 years and those aged 65 and over, and com- pared. Results: Anticholinergic agents were contraindicated in more than 50% of subjects aged 65 years and over, and glucagon was contraindicated in 11% of subjects aged 65 years and over. The proportion of elderly subjects in whom antispasmodic agents, including anticholinergics and glucagon, were contraindicated was significantly greater than for subjects aged under 65 years. Conclusions: Using a written questionnaire at the time of obtaining informed consent facilitates the identification of under- lying diseases and selection of appropriate premedication.
机译：目的：改善正在接受胃肠道（GI）检查的患者在潜在疾病和药物选择方面的风险管理。根据日本的一项全国性调查，与处方药相关的死亡人数中有74％是60岁以上的患者。方法：对象为2001年10月至2004年1月接受胃肠道检查（367内窥镜检查，51钡造影造影）的418例患者。年龄分布在65-69岁年龄组达到峰值，40％的受试者年龄在65岁和过度。使用调查表，在调查之前对每位受试者进行了采访，以确定抗胆碱能药物或胰高血糖素制剂的禁忌症。为了确定老年受试者中与解痉药有关的风险，将其分为65岁以下和65岁以上。结果：65岁及以上的受试者中有50％以上的人禁用抗胆碱药，65岁及以上的受试者中11％的患者有胰高血糖素禁忌症。禁忌使用抗痉挛药物（包括抗胆碱能药和胰高血糖素）的老年受试者的比例明显高于65岁以下的受试者。结论：在获得知情同意时使用书面问卷有助于识别潜在疾病和选择合适的药物治疗方法。

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