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首页> 外文期刊>Clinical ophthalmology >Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas
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Combined oral propranolol with intralesional injection of triamcinolone acetonide in treatment of infantile periocular hemangiomas

机译：普萘洛尔联合病灶内注射曲安奈德联合治疗小儿眼周血管瘤

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Aim: To evaluate the clinical effectiveness of combined oral propranolol with intralesional injection of triamcinolone acetonide in the treatment of infantile periorbital capillary hemangioma. Patients and Methods: This prospective interventional study included children diagnosed with periocular infantile hemangiomas in the proliferative phase with vision-threatening lesions. The children presented to the oculoplastic unit in Sohag University Hospital in the period between January 2016 and February 2017 and were treated with a combined intralesional injection of triamcinolone acetonide with oral propranolol, with a follow-up period of 6 months. Treatment response was evaluated according to the size of the tumor (horizontal diameter); additionally, complications of both treatment methods were recorded. Results: This study included 33 infants: 21 females (64%) and 12 males (36%). The mean age at the time of injection was 4.9±2.6 months. The study included three modes of treatment response: regression of the tumor, 28 patients (85%); stabilization, three patients (9%); and failure, two patients (6%), which necessitated repeated intralesional injection of triamcinolone but with minimal response. Regarding complications, only one patient reported with subconjunctival hemorrhage during intralesional injection of steroids; there were no recorded cases of hypotension, bradycardia, or hypoglycemia during the course of oral propranolol treatment. After the end of the follow-up period, there were no reported cases of recurrent increase in the size of the regressed group of infantile hemangiomas with stable tumor size. Conclusion: Combined oral propranolol with intralesional injection of triamcinolone acetonide is the effective method of treatment for infantile periorbital capillary hemangioma with minimal adverse effects.
机译：目的：评价口服普萘洛尔与病灶内注射曲安奈德联合治疗小儿眶周毛细血管瘤的临床疗效。患者和方法：这项前瞻性干预研究包括被诊断患有增生期眼周婴儿血管瘤并伴有视力损害的儿童。这些儿童于2016年1月至2017年2月期间就诊于Sohag大学医院的眼部整形科，并接受病灶内注射曲安奈德与普萘洛尔的联合病灶内注射治疗，为期6个月。根据肿瘤的大小（水平直径）评估治疗反应;另外，记录了两种治疗方法的并发症。结果：该研究包括33例婴儿：21例女性（64％）和12例男性（36％）。注射时的平均年龄为4.9±2.6个月。该研究包括三种治疗反应模式：肿瘤消退，28例（85％）;稳定，三名患者（9％）;和失败，两名患者（6％）需要病灶内反复注射曲安奈德，但反应最小。关于并发症，病灶内注射类固醇仅1例发生结膜下出血。口服普萘洛尔治疗期间无低血压，心动过缓或低血糖的病例记录。在随访期结束后，没有报告复发肿瘤大小稳定的婴儿血管瘤的复发。结论：口服普萘洛尔联合病灶内注射曲安奈德是治疗小儿眶周毛细血管瘤的有效方法，不良反应最小。

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