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首页> 外文期刊>Clinical Psychopharmacology and Neuroscience >Association of CDKN2B-AS1 rs1333049 with Brain Diseases: A Case-control Study and a Meta-analysis
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Association of CDKN2B-AS1 rs1333049 with Brain Diseases: A Case-control Study and a Meta-analysis

机译：CDKN2B-AS1 rs1333049与脑疾病的关联：病例对照研究和荟萃分析

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Objective CDKN2B-AS1 polymorphisms were shown to associate with the risk of stroke in European. The goal of this study was to evaluate the contribution of CDKN2B-AS1 rs1333049 to the risk of hemorrhagic stroke (HS) and brain tumor (BT) in Han Chinese. Methods A total of 142 HSs, 115 BTs, and 494 controls were included in the current association study. The genotyping test was performed using the melting temperature shift method. Results We failed to validate the association of CDKN2B-AS1 rs1333049 with the risk of brain disease. Significantly higher levels of low-density lipoprotein cholesterol (LDL-C) ( p =0.027), high-density lipoprotein cholesterol (HDL-C) ( p 0.05). The meta-analysis of 10 studies among 133,993 individuals concluded that rs1333049 of CDKN2B-AS1 gene was likely to increase a 16% incidence rate of cerebrovascular disease (CD) among various populations (odds ratio 1.16, 95% confidence interval 1.08–1.25; p <0.0001, random-effect method). Conclusion Our case-control study identified rs1333049 genotypes showed different association with the concentration of the LDL-C, HDL-C and TC in the HS patients. Meta-analysis supported the association between rs1333049 and CD risk in various populations, although we were unable to observe association between rs1333049 and the risk of HSs in Han Chinese.
机译：在欧洲，客观的CDKN2B-AS1多态性与卒中风险有关。这项研究的目的是评估中国汉族人CDKN2B-AS1 rs1333049对出血性中风（HS）和脑瘤（BT）风险的贡献。方法本研究共纳入142个HS，115个BT和494个对照。基因型分型试验使用熔融温度变化法进行。结果我们未能验证CDKN2B-AS1 rs1333049与脑病风险的相关性。低密度脂蛋白胆固醇（LDL-C）（p = 0.027）和高密度脂蛋白胆固醇（HDL-C）（p 0.05）明显较高。对133,993位个体中的10项研究进行的荟萃分析得出结论，CDKN2B-AS1基因的rs1333049可能使不同人群中的脑血管疾病（CD）发病率增加16％（几率1.16，95％置信区间1.08-1.25; p <0.0001，随机效应方法）。结论我们的病例对照研究确定了rs1333049基因型与HS患者中LDL-C，HDL-C和TC的浓度存在不同的关联。荟萃分析支持了rs1333049和CD风险在各种人群中的关联，尽管我们无法观察到rs1333049与汉族人群HS风险之间的关联。

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