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首页> 外文期刊>Clinical Pediatric Endocrinology >Osteoporosis and Spondylolisthesis after Comprehensive Treatment for Brain Tumor: A Case Report
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Osteoporosis and Spondylolisthesis after Comprehensive Treatment for Brain Tumor: A Case Report

机译：综合治疗脑肿瘤后的骨质疏松和腰椎滑脱症1例

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A 10-year-old boy who presented with hypopituitarism was diagnosed with supraseller germinoma based on the findings of brain magnetic resonance imaging (MRI). Dissemination of the tumor to the spinal cord was also evident. The patient was first treated with irradiation to both the brain and spinal cord, followed by chemotherapy with cisplatin (CDDP) and etoposide (VP-16). Peripheral blood stem cell transplantation (PBSCT) with extensive chemotherapy was performed when he was 14 years old. During and after the treatment for the brain tumor, he was placed on hormone replacement with corticosteroid hormone, l-thyroxine, and 1-deamino-8-D-arginine-vasopressin (DDAVP). Growth hormone was also replaced after 2 years from PBSCT. The patient was noted to have gait disturbance, osteoporosis and spondylolisthesis of the lumbar vertebrae (L) at 18 years old. His mean bone mineral density (BMD) of the 2nd to 4th lumbar vertebrae was 0.59 g/m2. There was no evidence of recurrence of the tumor. It is possible that a high dose of local irradiation, long-term corticosteroid hormone replacement, and a hypogonadal state are related to the onset and progression of the skeletal abnormalities.
机译：根据脑磁共振成像（MRI）的发现，一名患有垂体机能减退的10岁男孩被诊断​​为超上皮生殖器瘤。肿瘤向脊髓的扩散也很明显。该患者首先接受脑和脊髓照射，然后进行顺铂（CDDP）和依托泊苷（VP-16）化疗。他14岁时进行了广泛化疗的外周血干细胞移植（PBSCT）。在脑瘤治疗期间和之后，他被用皮质类固醇激素，1-甲状腺素和1-deamino-8-D-精氨酸-加压素（DDAVP）替代激素。从PBSCT提取2年后，生长激素也被替换。注意到该患者在18岁时有步态障碍，骨质疏松和腰椎（L）腰椎滑脱。他的第二至第四腰椎的平均骨矿物质密度（BMD）为0.59 g / m2。没有证据表明肿瘤复发。高剂量的局部照射，长期的皮质类固醇激素替代和性腺功能低下可能与骨骼异常的发生和发展有关。

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