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首页> 外文期刊>Clinical Pediatric Endocrinology >A Response to Human Chorionic Gonadotropin Test in Boys with Normal Gonadal Function and with Hypogonadism
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A Response to Human Chorionic Gonadotropin Test in Boys with Normal Gonadal Function and with Hypogonadism

机译：正常性腺功能减退症男孩对人绒毛膜促性腺激素测试的反应

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摘要

Data on standard values of human chorionic gonadotropin (hCG) stimulation in normal boys are limited. Moreover, data on participants definitely diagnosed with hypogonadism are rarely reported. Peak plasma testosterone (T) levels after hCG stimulation in a group of boys (2.0~20.9 years) with definitive primary hypogonadism (PH), secondary hypogonadism (SH) and normal gonadal function (N) were analysed. Peak T in groups of PH, SH and N were <0.1~1.9 ng/ml (below 2.0 ng/ml), 0.3~4.5 ng/ml, and 2.2~11.3 ng/ml, respectively. The lower cut-off point of response to hCG stimulation was 2.0 ng/ml and this value may be useful in the diagnosis of PH. Peak T in normal boys showed a tendency to increase after puberty, so a difference between PH and N might be more pronounced in the pubertal period than in the prepubertal period. On the other hand, it was sometimes difficult to make a diagnosis of SH based only on the hCG test, especially during pubertal period, since the T values for pubertal period overlapped between the SH and the N group. The evaluation of SH might be easily done during the pubertal period, if GnRH test were added in diagnosing SH.
机译：正常男孩的绒毛膜促性腺激素（hCG）刺激标准值的数据有限。而且，关于确诊为性腺机能减退的参与者的数据很少报道。分析了一组确定的原发性性腺功能减退（PH），继发性性腺功能减退（SH）和正常性腺功能（N）的男孩（2.0〜20.9岁）在hCG刺激后的血浆睾丸激素（T）峰值水平。 PH，SH和N组中的峰值T分别为<0.1〜1.9 ng / ml（低于2.0 ng / ml），0.3〜4.5 ng / ml和2.2〜11.3 ng / ml。对hCG刺激的最低反应阈值为2.0 ng / ml，该值可能有助于诊断PH。正常男孩的T峰在青春期后有增加的趋势，因此PH和N之间的差异在青春期可能比青春期前更为明显。另一方面，有时难以仅基于hCG试验来诊断SH，特别是在青春期，因为SH和N组之间的青春期T值重叠。如果在诊断SH时增加了GnRH测试，则在青春期期间可能很容易进行SH的评估。

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