Spectroscopic investigations of the oxidation of levofloxacin by hexacyanoferrate(III) in aqueous alkaline medium—A kinetic and mechanistic approach

Manjanath B. Patgar; Sharanappa T. Nandibewoor; Shivamurti A. Chimatadar

首页> 外文期刊>Cogent Chemistry >Spectroscopic investigations of the oxidation of levofloxacin by hexacyanoferrate(III) in aqueous alkaline medium—A kinetic and mechanistic approach

【24h】

Spectroscopic investigations of the oxidation of levofloxacin by hexacyanoferrate(III) in aqueous alkaline medium—A kinetic and mechanistic approach

机译：碱性介质中六氰合铁酸酯（III）氧化左氧氟沙星的光谱研究-动力学和机理方法

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Kinetics and mechanism of oxidation of levofloxacin (LF) by hexacyanoferrate(III) in aqueous alkaline medium at constant ionic strength of 1.10?mol?dm~(?3) is studied spectrophotometrically. The reaction exhibits, 2:1, [Fe(CN)_(6)]~(3?):levofloxacin, stoichiometry. The main products identified are 9-fluoro-2,3- dihydro-6-hydroxy-3-methyl-10-(4-methylpiperazin-1-yl)–[1,4]oxazino[2,3,4-ij]quinolin-7-one and [Fe(CN)_(6)]~(4?) were isolated and identified with the help of TLC and characterized by FT-IR and GCMS. The reaction is first order in hexacyanoferrate(III) concentration but fractional order in both levofloxacin and alkali concentrations. Decrease in the dielectric constant of the medium results in a decrease in the rate of reaction. The effects of added products and ionic strength have also been investigated. A mechanism involving free radicals is proposed. In a composite equilibrium step, levofloxacin binds to hexacyanoferrate(III) to form a complex that subsequently decomposes to the products. Investigations of the reaction at different temperatures allowed the determination of the activation parameters with respect to the slow step of the proposed mechanism.

机译：用分光光度法研究了在恒定离子强度下，碱性水溶液中六氰合铁酸酯（III）氧化左氧氟沙星（LF）的动力学和机理。反应显示出2：1，[Fe（CN）_（6）]〜（3？）：左氧氟沙星，化学计量。确定的主要产品是9-氟-2,3-二氢-6-羟基-3-甲基-10-（4-甲基哌嗪-1-基）– [1,4]恶嗪[2,3,4-ij]借助TLC分离并鉴定了喹啉-7-one和[Fe（CN）_（6）]〜（4？），并通过FT-IR和GCMS对其进行了表征。该反应在六氰合铁酸酯（III）浓度中为一级，但在左氧氟沙星和碱浓度中均为分数级。介质的介电常数降低导致反应速率降低。还研究了添加产品和离子强度的影响。提出了一种涉及自由基的机制。在复合平衡步骤中，左氧氟沙星与六价铁氰化物（III）结合形成复合物，该复合物随后分解为产物。对在不同温度下反应的研究允许确定关于所提出机理的慢步的活化参数。

著录项

来源
《Cogent Chemistry》 |2015年第1期|共14页
作者
Manjanath B. Patgar; Sharanappa T. Nandibewoor; Shivamurti A. Chimatadar;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Spectroscopic Investigation and Reactivities of Ruthenium(III) Catalyzed Oxidation of Anticholinergic Drug Atropine Sulfate Monohydrate by Hexacyanoferrate(III) in Aqueous Alkaline Media: A Mechanistic Approach [J] . Manjunath D. Meti, Sharanappa T. Nandibewoor, Shivamurti A. Chimatadar Synthesis and reactivity in inorganic, metal-organic, and nano-metal chemistry . 2014,第1a3期

机译：六氰基铁酸盐（III）在碱性介质中钌（III）催化氧化抗胆碱能药物阿托品硫酸盐一水合物的光谱研究和反应性：一种机械方法
2. Kinetic and mechanistic investigations and thermodynamic quantities for different steps involved in the mechanism of oxidation of procainamide by hexacyanoferrate(III) in aqueous alkaline medium: a spectrophotometric study [J] . Meti M. D., Lamani M. H., Naikar A. G., Monatshefte fur Chemie . 2015,第9期

机译：碱性介质中分光光度法研究六氰合铁酸酯（III）氧化普鲁卡因酰胺机理的动力学和机理研究以及不同步骤的热力学量：
3. Oxidation of amoxicillin by hexacyanoferrate(III) in aqueous alkaline medium-A kinetic and mechanistic approach [J] . Durgannavar Amar K., Patgar Manjanath B., Chimatadar Shivamurti A. Indian Journal of Chemistry, Section A. Inorganic, Physical, Theoretical & Analytical . 2015,第9期

机译：碱性水介质中高铁酸三氰化物氧化阿莫西林的动力学机理
4. MECHANISTIC INVESTIGATIONS OF OXIDATION OF PURINE AND PYRIMIDINE BASE COMPONENTS OF NUCLEIC ACIDS BY BROMAMINE-B IN AQUEOUS ALKALINE MEDIUM : A KINETIC APPROACH [C] . Nirmala Vaz, Puttaswamy 3rd International Symposium on Reaction Kinetics and the Development and Operation of Catalytic Processes, Apr 22-25, 2001, Oostende, Belgium . 2001

机译：碱性介质中溴胺-B对嘌呤和嘧啶碱成分氧化的机理研究：一种动力学方法
5. I. THE ELECTROCHEMISTRY OF NITRIC OXIDE AND A NITROUS ACID AT A MERCURY ELECTRODE IN AQUEOUS SOLUTIONS. II. ELECTROCHEMISTRY AND HYDROLYSIS KINETICS OF THE 2,2'-BIPYRIDINE COMPLEXES OF IRON(III) AND IRON(II); ELECTROCHEMICAL KINETIC PARAMETERS FOR SEVERAL IRON COMPLEXES. III. PROTON NUCLEAR MAGNETIC RESONANCE STUDIES OF URANIUM(IV)-ETHYLENE DIAMINETETRAACETIC ACID COMPLEXES IN AQUEOUS (DEUTERIUM-OXIDE) SOLUTIONS. [D] . EHMAN, DEWAYNE LEE. 1969

机译：I.水溶液中汞电极上一氧化二氮和亚硝酸的电化学二。铁（III）和铁（II）的2,2'-联吡啶络合物的电化学和水解动力学；多种铁络合物的电化学动力学参数。三，铀（IV）-水溶液（氧化氘）中铀（IV）-乙撑双氨基乙酸复合物的质子核磁共振研究
6. Mechanistic studies of uncatalyzed and ruthenium(III)-catalyzed oxidation of the antibiotic drug chloramphenicol by hexacyanoferrate(III) in aqueous alkaline medium: a comparative kinetic study [O] . M. D. Meti, K. S. Byadagi, S. T. Nandibewoor, -1

机译：六氰合铁酸盐（III）在碱性水溶液中未催化和钌（III）催化抗生素氯霉素氧化的机理：动力学比较研究
7. Spectroscopic investigations of the oxidation of levofloxacin by hexacyanoferrate(III) in aqueous alkaline medium—A kinetic and mechanistic approach [O] . Manjanath B. Patgar, Sharanappa T. Nandibewoor, Shivamurti A. Chimatadar 2015

机译：六氰基铁酸盐（III）在含水碱性介质中氧化左氧氟沙星的光谱研究 - 动力学和机械学方法
8. Spectroscopic Studies of the Passive Film on Alkali and Alkaline Earth Metals in Non-Aqueous Solvents: A Surface Science Approach, Final Report. [R] . Herrera-Fierro, P., Xing, X., Chottiner, G., 1988

机译：非水溶剂中碱金属和碱土金属被动膜的光谱研究：表面科学方法，最终报告。

Spectroscopic investigations of the oxidation of levofloxacin by hexacyanoferrate(III) in aqueous alkaline medium—A kinetic and mechanistic approach

摘要

著录项

相似文献

相关主题

期刊订阅