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首页> 外文期刊>Cogent Chemistry >Oxidation of clindamycin phosphate by chromium(VI) in aqueous sulfuric acid medium—A kinetic and mechanistic study
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Oxidation of clindamycin phosphate by chromium(VI) in aqueous sulfuric acid medium—A kinetic and mechanistic study

机译：硫酸介质中铬（VI）氧化磷酸克林霉素的动力学和机理研究

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Kinetics and mechanism of oxidation of clindamycin phosphate by potassium dichromate in aqueous sulfuric acid medium is studied spectrophotometrically at 25°C at a constant ionic strength of 3.60?mol?dm~(?3). The stoichiometry of the reaction is determined and it was found that one mole of clindamycin phosphate consumes two moles of chromium(VI) (1:2). The oxidation products are characterized and confirmed by spectral studies such as IR, GC-MS and LC-MS. The reaction is first order each in chromium(VI) and clindamycin phosphate concentrations. An increase in the sulfuric acid concentration causes an increase of the reaction rate. The order with respect to acid concentration is found to be 1.65. From the results of kinetic studies, reaction stoichiometry and product analysis a suitable free radical mechanism is proposed. Based on investigation of the reaction at different temperatures, computation of the activation parameters with respect to the slow step of the proposed mechanism was evaluated.
机译：在25°C，3.60？mol？dm〜（？3）的恒定离子强度下，用分光光度法研究了硫酸铬水溶液中重铬酸钾对克林霉素磷酸的氧化动力学和机理。确定反应的化学计量，发现一摩尔的克林霉素磷酸酯消耗两摩尔的铬（VI）（1∶2）。通过光谱研究（例如IR，GC-MS和LC-MS）对氧化产物进行表征和确认。该反应以铬（VI）和磷酸克林霉素的浓度为一级。硫酸浓度的增加引起反应速率的增加。发现相对于酸浓度的顺序为1.65。从动力学研究，反应化学计量和产物分析的结果，提出了合适的自由基机理。基于在不同温度下反应的研究，评估了相对于所提出机理的慢步的活化参数的计算。

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