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首页> 外文期刊>Clinical diabetes and endocrinology. >The cost-effectiveness of diabetes prevention: results from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study
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The cost-effectiveness of diabetes prevention: results from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study

机译：糖尿病预防的成本效益：糖尿病预防计划和糖尿病预防计划结果研究的结果

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Background The Diabetes Prevention Program (DPP) was a randomized, controlled clinical trial. It demonstrated that among high-risk individuals with impaired glucose tolerance, diabetes incidence was reduced by 58?% with lifestyle intervention and 31?% with metformin compared to placebo. During the Diabetes Prevention Program Outcomes Study (DPPOS), all DPP participants were unmasked to their treatment assignments, the original lifestyle intervention group was offered additional lifestyle support, the metformin group continued metformin, and all three groups were offered a group-implemented lifestyle intervention. Over the 10?years of combined DPP/DPPOS follow-up, diabetes incidence was reduced by 34?% in the lifestyle group and 18?% in the metformin group compared to placebo. The purpose of this article is to review and synthesize analyses published by the DPP/DPPOS Research Group that have described the cost-effectiveness of diabetes prevention.
机译：背景糖尿病预防计划（DPP）是一项随机对照临床试验。研究表明，与安慰剂相比，在糖耐量受损的高危人群中，生活方式干预降低了糖尿病的发生率，二甲双胍降低了31％的糖尿病发生率。在糖尿病预防计划结果研究（DPPOS）中，所有DPP参与者均未接受治疗任务的安排，为原始生活方式干预组提供了额外的生活方式支持，二甲双胍组继续使用二甲双胍，为所有三个组提供了小组实施的生活方式干预。与安慰剂相比，在DPP / DPPOS联合随访的10年中，生活方式组的糖尿病发生率降低了34％，二甲双胍组的糖尿病发生率降低了18％。本文的目的是回顾和综合由DPP / DPPOS研究小组发布的分析，这些分析描述了预防糖尿病的成本效益。

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