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首页> 外文期刊>Clinical Pediatric Endocrinology >Favorable Impacts of Growth Hormone (GH) Replacement Therapy on Atherogenic Risks in Japanese Children with GH Deficiency
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Favorable Impacts of Growth Hormone (GH) Replacement Therapy on Atherogenic Risks in Japanese Children with GH Deficiency

机译：生长激素（GH）替代疗法对日本GH缺乏症儿童致动脉粥样硬化风险的有利影响

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摘要

Growth hormone (GH) affects body composition and atherogenic risk factors. Severe hyperlipidemia may develop in GH-deficient adults as a consequence of continuous GH deficiency. We investigated changes in lipid profiles in 158 Japanese children (103 boys and 55 girls) with GH deficiency who had been enrolled in the Pfizer International Growth Database Japan during 3 yr of GH replacement therapy to evaluate whether GH treatment has beneficial effects on atherogenic risk factors. Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC) and atherogenic index were evaluated before treatment and then once a year during treatment. The mean baseline TC was within the normal range in both boys and girls. Seventeen (16.5%) of the 103 boys and 18 (32.7%) of the 55 girls, however, had a TC level over 200 mg/dl before treatment. The mean TC level showed a significant decrease in girls. In a separate analysis, patients of both sexes with a TC level > 200 mg/dl showed significantly decreased TC. LDLC decreased significantly only in girls, while HDLC showed no change in either sex. The atherogenic index decreased significantly in girls. GH replacement therapy in children with GH deficiency had beneficial effects on lipid metabolism and atherogenic risk in both sexes. Early GH treatment would produce lipid metabolism benefits in these patients.
机译：生长激素（GH）影响身体成分和动脉粥样硬化危险因素。由于持续的GH缺乏，在GH缺乏的成年人中可能发展为严重的高脂血症。我们调查了在GH替代疗法治疗3年期间加入辉瑞国际生长数据库日本的158名GH缺乏的日本儿童（103名男孩和55名女孩）的脂质谱变化，以评估GH治疗是否对动脉粥样硬化危险因素具有有益作用。在治疗前评估总胆固醇（TC），高密度脂蛋白胆固醇（HDLC），低密度脂蛋白胆固醇（LDLC）和动脉粥样硬化指数，然后在治疗期间每年评估一次。男孩和女孩的平均基线TC均在正常范围内。 103名男孩中的十七名（16.5％）和55名女孩中的18名（32.7％）在治疗前的TC水平超过200 mg / dl。平均TC水平显示女孩的显着下降。在单独的分析中，TC水平> 200 mg / dl的男女患者均显示TC显着降低。 LDLC仅在女孩中显着下降，而HDLC在两性中均无变化。女孩的动脉粥样硬化指数显着下降。 GH缺乏症儿童的GH替代疗法对男女的脂质代谢和动脉粥样硬化风险具有有益作用。早期GH治疗将在这些患者中产生脂质代谢益处。

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