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Visualizing Protein Interactions and Dynamics: Evolving a Visual Language for Molecular Animation

机译：可视化蛋白质相互作用和动力学：为分子动画发展视觉语言

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Undergraduate biology education provides students with a number of learning challenges. Subject areas that are particularly difficult to understand include protein conformational change and stability, diffusion and random molecular motion, and molecular crowding. In this study, we examined the relative effectiveness of three-dimensional visualization techniques for learning about protein conformation and molecular motion in association with a ligand–receptor binding event. Increasingly complex versions of the same binding event were depicted in each of four animated treatments. Students (n = 131) were recruited from the undergraduate biology program at University of Toronto, Mississauga. Visualization media were developed in the Center for Molecular and Cellular Dynamics at Harvard Medical School. Stem cell factor ligand and cKit receptor tyrosine kinase were used as a classical example of a ligand-induced receptor dimerization and activation event. Each group completed a pretest, viewed one of four variants of the animation, and completed a posttest and, at 2 wk following the assessment, a delayed posttest. Overall, the most complex animation was the most effective at fostering students' understanding of the events depicted. These results suggest that, in select learning contexts, increasingly complex representations may be more desirable for conveying the dynamic nature of cell binding events.
机译：本科生物学教育为学生提供了许多学习挑战。特别难以理解的主题领域包括蛋白质构象变化和稳定性，扩散和随机分子运动以及分子拥挤。在这项研究中，我们研究了三维可视化技术在与配体-受体结合事件有关的蛋白质构象和分子运动方面的相对有效性。在四个动画处理的每一个中，都描述了相同绑定事件的越来越复杂的版本。学生（n = 131）是从密西沙加的多伦多大学的本科生物学课程招募的。可视化媒体是在哈佛医学院分子与细胞动力学中心开发的。干细胞因子配体和cKit受体酪氨酸激酶被用作配体诱导受体二聚化和激活事件的经典例子。每个小组都完成了预测试，查看了动画的四个变体之一，并完成了后测试，并在评估后2周完成了延迟的后测试。总体而言，最复杂的动画最有效地促进了学生对所描述事件的理解。这些结果表明，在选择的学习环境中，越来越复杂的表示对于传达细胞结合事件的动态性质可能更为理想。

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