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首页> 外文期刊>Cogent Chemistry >Flavonoids from Artocarpus hirsutus Lam: Synthesis of new prenyl ethers, acetates and their anti-acne activity
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Flavonoids from Artocarpus hirsutus Lam: Synthesis of new prenyl ethers, acetates and their anti-acne activity

机译：面包果黄酮的类黄酮：新异戊二烯基醚，乙酸酯的合成及其抗痤疮活性

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摘要

Artocarpus hirsutus Lam., one of the species of Artocarpus, is not well studied. The present study is intended to isolate the chemical constituents present in stem wood extract of A. hirsutus , to synthesize their new derivatives and to evaluate their activity against Propionibacterium acnes . Three major flavonoids, cudraflavone A, cycloartocarpin and artocarpin were isolated from the stem wood extract and cudraflavone A was isolated for the first time from this plant. New prenyl ether and acetate derivatives of isolated flavonoids have been synthesized. This is the first to report on the evaluation of in vitro anti-acne potential of crude extracts, isolated flavonoids and their new synthetic derivatives. The crude extracts (MIC values 2, 4 and 15.6?μg/mL) and the isolated constituents (MIC values 2, 0.5 and 0.25?μg/mL) showed significant in vitro anti-acne activity against P. acnes which was comparable with commercially available anti-acne agent, tea tree, oil and a standard antibiotic, Clindamycin (MIC 0.03?μg/mL) indicating their potential as anti-acne agents.
机译：面包果的一种 Artocarpus hirsutus Lam。，没有得到很好的研究。本研究旨在分离A茎木提取物中存在的化学成分。 hirsutus，以合成其新衍生物并评估其对痤疮丙酸杆菌的活性。从茎木提取物中分离出三种主要的类黄酮，葫芦黄酮A，环arcarpocar​​pin和木瓜蛋白酶，并首次从该植物中分离出葫芦黄酮A。已经合成了分离的类黄酮的新异戊二烯醚和乙酸酯衍生物。这是第一个关于粗提物，分离的类黄酮及其新合成衍生物体外抗粉刺潜力评估的报告。粗提物（MIC值分别为2、4和15.6？g / mL）和分离出的成分（MIC值分别为2、0.5和0.25？g / mL）显示出显着的体外抗粉刺活性。与市售抗痤疮剂，茶树，油和标准抗生素克林霉素（MIC 0.03？μg/ mL）相当的痤疮，表明它们具有抗痤疮剂的潜力。

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