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首页> 外文期刊>Cogent Chemistry >Qualitative and quantitative analyses of methamphetamine in hair following derivatization with trifluoroacetic acid or heptafluorobutyric acid anhydride
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Qualitative and quantitative analyses of methamphetamine in hair following derivatization with trifluoroacetic acid or heptafluorobutyric acid anhydride

机译：三氟乙酸或七氟丁酸酐衍生化后的头发中甲基苯丙胺的定性和定量分析

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Illicit drug use and its consequence necessitate the development of identification methods for the target drugs in biological materials. Methamphetamine (MA) is a psychotropic substance with short elimination half-life in urine and blood; however, negative consequences of MA use may last for a long time. So, its diagnosis is essential even long after MA exposure. A total of 50 hair specimens were obtained from those with a history of MA abuse from addiction treatment camps. A gas chromatography–mass spectrometry (GC-MS) analysis was developed to identify MA using trifluoroacetic acid (TFA) or heptafluorobutyric acid anhydride (HFBA) as two derivatization agents. It was indicated that these subjects were 80 and 8% negative for MA following derivatization with HFBA and TFA, respectively. The limits of detection and quantitation for derivatization with TFA were 0.2 and 0.6?ng/mg. In conclusion, use of TFA in GC-MS can afford to effectively dissolve MA out of the hair matrix. This dissolving procedure has easy procurement with high applicability and validity.
机译：非法使用毒品及其后果有必要发展生物材料中目标药物的鉴定方法。甲基苯丙胺（MA）是一种精神药物，在尿液和血液中的消除半衰期较短;但是，使用MA的负面后果可能会持续很长时间。因此，即使在MA暴露后很长时间，其诊断也必不可少。从成瘾治疗营地有MA滥用史的人那里获得了总共50个头发样本。气相色谱-质谱（GC-MS）分析法已开发出来，以使用三氟乙酸（TFA）或七氟丁酸酐（HFBA）作为两种衍生剂来鉴定MA。结果表明，在用HFBA和TFA衍生化后，这些受试者的MA分别为80％和8％阴性。用TFA衍生化的检测和定量限为0.2和0.6？ng / mg。总之，在GC-MS中使用TFA可以有效地将MA从头发基质中溶解出来。该溶解步骤易于采购，具有较高的适用性和有效性。

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