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首页> 外文期刊>Comparative and functional genomics >Association of Polymorphisms in the HumanIL4andIL5Genes with Atopic Bronchial Asthma and Severity of the Disease
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Association of Polymorphisms in the HumanIL4andIL5Genes with Atopic Bronchial Asthma and Severity of the Disease

机译：HumanIL4和IL5基因多态性与特应性支气管哮喘和疾病严重程度的关系

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摘要

Two polymorphisms in theIL4(G/C 3′-UTR) andIL5(C-703T) genes were studied in a sample of families whose probands had atopic bronchial asthma (BA) (66 families,n = 183) and in a group of non-cognate individuals with the severe form of the disease(n = 34). The samples were collected from the Russian population in the city of Tomsk(Russia). Using the transmission/disequilibrium test (TDT), a significant associationof allele C-703IL5with BA was established (TDT = 4.923,p= 0.007 ± 0.0007). Theanalysis of 40 individuals with mild asthma and 49 patients with the severe formof the disease revealed a negative association of genotype GGIL4(OR = 0.39, 95%CI = 0.15?0.99,p= 0.035), and also a trend towards a positive association of theGCIL4genotype (OR = 2.52, 95% CI = 0.98?6.57,p= 0.052) with mild BA. Therewas a concordance of the clinical classification of BA severity with the ‘genotype’(McNemar'sχ2test with continuity correction constituted 0.03, d.f. = 1,p= 0.859).These results suggest that polymorphisms in theIL4andIL5genes contribute to thesusceptibility to atopic BA and could determine the clinical course of the disease.
机译：在先证者患有特应性支气管哮喘（BA）的家庭（66个家庭，n = 183）和一组非IL4（G / C 3'-UTR）和IL5（C-703T）基因中研究了两个多态性。 -患有严重疾病的同伴（n = 34）。样本是从俄罗斯托木斯克市的俄罗斯人口中收集的。使用传输/不平衡测试（TDT），建立了等位基因C-703IL5与BA的显着关联（TDT = 4.923，p = 0.007±0.0007）。对40例轻度哮喘患者和49例严重疾病患者的分析显示，基因型GGIL4呈负相关（OR = 0.39，95％CI = 0.15？0.99，p = 0.035），并且呈正相关的趋势。具有轻度BA的GCIL4基因型（OR = 2.52，95％CI = 0.98？6.57，p = 0.052）。 BA严重程度的临床分类与“基因型”一致（McNemar的χ2检验，经连续性校正构成0.03，df = 1，p = 0.859）。这些结果表明IL4和IL5基因的多态性有助于特应性BA的敏感性，并可以确定该疾病的临床过程。

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