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首页> 外文期刊>Comparative Medicine >Latissimus Dorsi Cardiomyoplasty: A Chronic Experimental Porcine Model. Feasibility Study of Cardiomyoplasty in Danish Landrace Pigs and G?ttingen Minipigs
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Latissimus Dorsi Cardiomyoplasty: A Chronic Experimental Porcine Model. Feasibility Study of Cardiomyoplasty in Danish Landrace Pigs and G?ttingen Minipigs

机译：背阔肌心肌成形术：慢性实验性猪模型。丹麦长白猪和格廷根小型猪进行心肌成形术的可行性研究

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Cardiomyoplastyisanexperimentaltreatmentforend-stageheartfailure.Wehypothesizedthattheporcinelatissimusdorsimuscle(LDM)inanexperimentalporcinemodelisasuitablesurrogateforaclinicallyrelevantevaluationofthisconcept.FourteenDanishLandrace(DL)pigsandsixG?ttingenminipigs(GM)werestudied.TheLDMwasevaluatedimmediatelyaftersurgicaldissectionandinvariousphases:phase1(n=4)#8212;outcomeofapartialvascularisolation(vasculardelay),2to3weekspriortoheartwrappinginDLpigs;phase2(n=6)#8212;long-termflapsurvivalofnonstimulatedLDMcardiomyoplastyinDLpigs;phase3(n=6)#8212;outcomeofnonstimulatedcardiomyoplastyinGM;phase4#8212;oneDLpighaddynamiccardiomyoplastyperformedandwassubjectedtolow-intensityLDMstimulationfor8months.brxmlns="http://pub2web.metastore.ingenta.coms/"/brIsolationoftheLDMofDLpigsandGMasapedicledgrafthadnoacutedeleteriousimpactontheglobalbloodsupply.Inphase1a,partialvascularisolationandinsiturecoveryoftheLDMresultedinamuscleencapsulatedinfibrotictissue,whichhamperedalaterheartwrap.Inphase1b,alessextensivedissectiondiminishedfibrosisandallowedsubsequentwrapping.Inphase2,after6weeksofnonstimulatedLDMcardiomyoplasty,theLDMofDLpigswasviable,withexcellentheart-muscleintegration.Inphase3,thesameprocedureappliedinGMyieldedthesameresultasthatinDLpigs,butwithahighersuccessrateowingtothelearningphase.
机译：Cardiomyoplastyisanexperimentaltreatmentforend-stageheartfailure.Wehypothesizedthattheporcinelatissimusdorsimuscle（LDM）inanexperimentalporcinemodelisasuitablesurrogateforaclinicallyrelevantevaluationofthisconcept.FourteenDanishLandrace（DL）pigsandsixG ttingenminipigs（GM）werestudied.TheLDMwasevaluatedimmediatelyaftersurgicaldissectionandinvariousphases：阶段1（N = 4）＃8212; outcomeofapartialvascularisolation（vasculardelay），2to3weekspriortoheartwrappinginDLpigs;阶段2（N = 6）＃8212;长-termflapsurvivalofnonstimulatedLDMcardiomyoplastyinDLpigs;阶段3（N = 6）＃8212; outcomeofnonstimulatedcardiomyoplastyinGM; phase4＃8212; oneDLpighaddynamiccardiomyoplastyperformedandwassubjectedtolow-intensityLDMstimulationfor8months IsolationoftheLDMofDLpigsandGMasapedicledgrafthadnoacutedeleteriousimpactontheglobalbloodsupply.Inphase1a， LDM的部分血管隔离和缝合线的发现是在肌肉包裹的纤维化组织中进行的，这阻碍了心脏的包裹。第1b阶段，在不刺激的LDM心肌整形手术6周后，DL猪的LDM可行，并具有良好的心肌整合能力。第3阶段，通过GM进行相同的处理，直到DL的结果相同。

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