Paeoniflorin Prevents Diabetic Nephropathy in Rats

Fu Jianfang; Li Yuan; Wang Li; Gao Bin; Zhang Nanyan; Ji Qiuhe

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Paeoniflorin Prevents Diabetic Nephropathy in Rats

机译：eon药苷预防大鼠糖尿病性肾病

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Theaimofthisstudywastotestthehypothesisthatpaeoniflorinpreventstheprogressionofdiabeticnephropathybymodulatingtheinflammatoryprocess.Sprague#8211;Dawleyratsweredividedinto5groups:nondiabeticcontrolrats;untreateddiabeticmodel(DM)rats;andDMratstreatedwith5,10,or20mg/kgpaeoniflorinindrinkingwateroncedaily.Ratsreceivedasingleintravenousinjectionofstreptozotocintoinducediabetes;9wkafterinjection,ratsbeganthe8-wkdailypaeoniflorintreatmentregimen.ComparedwiththatofnonDMcontrols,theurinaryalbumin:creatinineratiowasincreasedsignificantlyinuntreatedDMrats;thisratiowasdecreasedinDMratstreatedwith5,10,or20mg/kgpaeoniflorincomparedwiththatofuntreatedDMrats.Inaddition,paeoniflorintreatmenteffectivelysuppressedglomerularhypertrophy;bloodglucose;theexpressionoftransforminggrowthfactor#59137;,typeIVcollagen,andintercellularadhesionmolecule1;andrenalinfiltrationofmacrophagescomparedwithlevelsinuntreatedDMrats.Furthermore,renalnuclearfactor#59153;Bactivitywasincreasedinuntreatedbutnotpaeoniflorin-treatedDMrats.Inconclusion,ourdatasuggestthatthepreventiveeffectsofpaeoniflorinmaybemediatedbyitsantiinflammatoryactions.

机译：Theaimofthisstudywastotestthehypothesisthatpaeoniflorinpreventstheprogressionofdiabeticnephropathybymodulatingtheinflammatoryprocess.Sprague＃8211; Dawleyratsweredividedinto5groups：nondiabeticcontrolrats; untreateddiabeticmodel（DM）的大鼠; andDMratstreatedwith5,10，or20mg / kgpaeoniflorinindrinkingwateroncedaily.Ratsreceivedasingleintravenousinjectionofstreptozotocintoinducediabetes; 9wkafterinjection，ratsbeganthe8-wkdailypaeoniflorintreatmentregimen.ComparedwiththatofnonDMcontrols，theurinaryalbumin：creatinineratiowasincreasedsignificantlyinuntreatedDMrats; thisratiowasdecreasedinDMratstreatedwith5,10，or20mg / kgpaeoniflorincomparedwiththatofuntreatedDMrats.Inaddition，paeoniflorintreatmenteffectivelysuppressedglomerularhypertrophy;血糖;转化生长因子＃59137的表达; IV型胶原和细胞间粘附分子1;与未经处理的DM大鼠水平相比，巨噬细胞的肾浸润。此外，肾核因子＃59153;未经处理但经B药苷处理的活性增加DM大鼠。结论是，我们的数据表明，flor药苷的预防作用可能是由其抗炎作用所介导的。

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《Comparative Medicine》 |2009年第6期|共页
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Fu Jianfang; Li Yuan; Wang Li; Gao Bin; Zhang Nanyan; Ji Qiuhe;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Paeoniflorin Prevents Diabetic Nephropathy in Rats. [J] . Fu Jianfang, Li Yuan, Wang Li, Comparative Medicine . 2009,第6期

机译：eon药苷可预防大鼠糖尿病性肾病。
2. In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy. [J] . Nangaku M, Izuhara Y, Usuda N, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2005,第12期

机译：在2型糖尿病肾病大鼠模型中，通过低卡路里饮食改善肥胖症可减少氧化/羰基应激反应并预防糖尿病肾病。
3. Additive effects of cilnidipine and angiotensin II receptor blocker in preventing the progression of diabetic nephropathy in diabetic spontaneously hypertensive rats [J] . AritomiS., NiinumaK., OgawaT., Clinical and experimental nephrology . 2013,第1期

机译：西尼地平和血管紧张素II受体阻滞剂在预防糖尿病自发性高血压大鼠糖尿病肾病中的作用
4. Swallow nest extract can be able to prevent nephropathy diabetic of the white rats streptozotocin-induced [C] . T Triawanti, F D Alexandra, A Frethernity, International Seminar on Smart Molecule of Natural Resources . 2020

机译：燕窝巢提取物可以能够防止白鼠肾病糖尿病链脲佐菌素诱导的
5. Pyrazinoylguanidine attenuates diabetic nephropathy and prevents cataractogenesis in STZ-diabetic rats. [D] . Follansbee, Mark Howard. 1997

机译：吡嗪酰基胍可减轻糖尿病性肾病，并预防STZ糖尿病大鼠的白内障发生。
6. Paeoniflorin Ameliorates Macrophage Infiltration and Activation by Inhibiting the TLR4 Signaling Pathway in Diabetic Nephropathy [O] . Yun-xia Shao, Qian Gong, Xiang-Ming Qi, -1

机译：eon药苷通过抑制糖尿病肾病中的TLR4信号通路来改善巨噬细胞的浸润和激活
7. Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy [O] . Tingmin Zhang, Qijin Zhu, Yunxia Shao, 2017

机译：Paeoniflorin可防止TLR2 / 4介导的2型糖尿病肾病中的炎症

Paeoniflorin Prevents Diabetic Nephropathy in Rats

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