Serologic Evaluation of Clinical and Subclinical Secondary Hepatic Amyloidosis in Rhesus Macaques (Macaca mulatta)

MacGuire Jamus G; Christe Kari L; Yee JoAnn L; Kalman-Bowlus Alexis L; Lerche Nicholas W

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Serologic Evaluation of Clinical and Subclinical Secondary Hepatic Amyloidosis in Rhesus Macaques (Macaca mulatta)

机译：恒河猴（猕猴）的临床和亚临床继发性肝淀粉样变性的血清学评估

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Secondaryhepaticamyloidosisinnonhumanprimatescarriesagraveprognosisonceanimalsbecomeclinicallyill.Thepurposeofthisstudywastoestablishserologicparametersthatpotentiallycouldbeusedtoidentifyrhesusmacaquesundergoingsubclinicaldevelopmentofsecondaryhepaticamyloidosis.Aretrospectiveanalysiswascompletedbyusingserumbiochemicalprofilesfrom26histologicallydiagnosedamyloidoticmacaquesevaluatedat2stagesofdisease,clinicalandsubclinical(3to32mopriortoclinicalsignsofdisease).Standardserumbiochemistryvaluesforcaseswerecomparedwithinstitutionalage-andgender-specificreferencesrangesbyconstructionof95%confidenceintervalsforthedifferencebetweenmeans.Inaddition,19histologicallydiagnosedamyloidoticmacaquesand19age-matchedcontrolswereassayedforchangesinvariousparametersbyusingroutinelybanked,frozen(#8211;80°C)seraavailablefromclinicalandsubclinicaltimepoints.Clinicallyamyloidoticanimalsdisplayedincreasedlevelsofalkalinephosphatase,aspartateaminotransferase,lactatedehydrogenase,gammaglutamyltranspeptidase,andmacrophagecolony-stimulatingfactorandsignificantlydecreasedquantitiesofalbuminandtotalcholesterol.Subclinicalamyloidoticanimalsdisplayedincreasedlevelsofalkalinephosphatase,aspartateaminotransferase,lactatedehydrogenase,andserumamyloidAanddecreasedconcentrationsofalbuminandtotalcholesterol.Theserologicparametersstudiedindicateatemporalrelationshipofthesefactorsnotpreviouslydescribed,showaclearpatternofdiseaseprogression,andcouldbeusefulinsubclinicaldiseasedetection.

机译：Secondaryhepaticamyloidosisinnonhumanprimatescarriesagraveprognosisonceanimalsbecomeclinicallyill.Thepurposeofthisstudywastoestablishserologicparametersthatpotentiallycouldbeusedtoidentifyrhesusmacaquesundergoingsubclinicaldevelopmentofsecondaryhepaticamyloidosis.Aretrospectiveanalysiswascompletedbyusingserumbiochemicalprofilesfrom26histologicallydiagnosedamyloidoticmacaquesevaluatedat2stagesofdisease，clinicalandsubclinical（3to32mopriortoclinicalsignsofdisease）.Standardserumbiochemistryvaluesforcaseswerecomparedwithinstitutionalage-andgender-specificreferencesrangesbyconstructionof95％confidenceintervalsforthedifferencebetweenmeans.Inaddition，19histologicallydiagnosedamyloidoticmacaquesand19age-matchedcontrolswereassayedforchangesinvariousparametersbyusingroutinelybanked，冷冻（＃8211; 80℃）seraavailablefromclinicalandsubclinicaltimepoints.Clinicallyamyloidoticanimalsdisplayedincreasedlevelsofalkalinephosphatase，aspartateaminotransferase，乳酸脱氢酶，gammaglutamyltranspeptidase，一个dmacrophagecolony-stimulatingfactorandsignificantlydecreasedquantitiesofalbuminandtotalcholesterol.Subclinicalamyloidoticanimalsdisplayedincreasedlevelsofalkalinephosphatase，aspartateaminotransferase，乳酸脱氢酶，andserumamyloidAanddecreasedconcentrationsofalbuminandtotalcholesterol.Theserologicparametersstudiedindicateatemporalrelationshipofthesefactorsnotpreviouslydescribed，showaclearpatternofdiseaseprogression，andcouldbeusefulinsubclinicaldiseasedetection。

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《Comparative Medicine》 |2009年第2期|共页
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MacGuire Jamus G; Christe Kari L; Yee JoAnn L; Kalman-Bowlus Alexis L; Lerche Nicholas W;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Serologic evaluation of clinical and subclinical secondary hepatic amyloidosis in rhesus macaques (Macaca mulatta) [J] . MacGuire JG, Christe KL, Yee JL, Comparative Medicine . 2009,第2期

机译：恒河猴（猕猴）的临床和亚临床继发性肝淀粉样变性的血清学评估
2. Alterations in Cytokines and Effects of Dexamethasone Immunosuppression during Subclinical Infections of Invasive Klebsiella pneumoniae with Hypermucoviscosity Phenotype in Rhesus (Macaca mulatta) and Cynomolgus (Macaca fascicularis) Macaques. [J] . Burke Robin L., West Michael W., Erwin-Cohen Rebecca, Comparative Medicine . 2010,第1期

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4. Retinal functional and morphological comparisons of two different macaque species, Macaca mulatta and Macaca fasicularis, for models of laser eye injury [C] . Cheryl D. DiCarlo, Henry D. Hacker, Araceli Brown, Photonic Therapeutics and Diagnostics; Progress in Biomedical Optics and Imaging; vol.6, no.1 . 2005

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6. Serologic Evaluation of Clinical and Subclinical Secondary Hepatic Amyloidosis in Rhesus Macaques (Macaca mulatta) [O] . Jamus G MacGuire, Kari L Christe, JoAnn L Yee, 2009

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7. Serologic host response to Helicobacter pylori and Campylobacter jejuni in socially housed Rhesus macaques (Macaca mulatta) [O] . Sabine Kienesberger, Guillermo I Perez-Perez, Juan L Rivera-Correa, 2012

机译：在社会收容的猕猴中对幽门螺杆菌和空肠弯曲杆菌的血清学宿主反应

Serologic Evaluation of Clinical and Subclinical Secondary Hepatic Amyloidosis in Rhesus Macaques (Macaca mulatta)

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