Immune Response to and Histopathology of Campylobacter jejuni Infection in Ferrets (Mustela putorius furo)

Nemelka Kevin W; Brown Ammon W; Wallace Shannon M; Jones Erika; Asher Ludmila V; Pattarini Dawn; Applebee Lisa; Gilliland Theron C; Guerry Patricia; Baqar Shahida

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Immune Response to and Histopathology of Campylobacter jejuni Infection in Ferrets (Mustela putorius furo)

机译：对雪貂空肠弯曲杆菌感染的免疫反应和组织病理学

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Campylobacterjejuniis1ofthemostcommonentericbacterialpathogensworldwide.Themechanismsofpathogenesisremainobscure,inpartbecauseoflimitationsofsmallanimalmodels.YoungferretsdevelopdiarrheawhenfedC.jejuni,buttheirpathologyandtheimmuneresponseafterinfectionhavenotbeenexaminedindetail.Inthepresentstudy,weexaminedthepathogenesisofC.jejuniCG8421andassociatedimmuneresponsesinferrets.AfteroralinfectionwithC.jejuniCG8421,86.7%oftheanimalsdevelopeddiarrheaandinflammatoryresponsesthatweresimilartothoseseeninhumaninfection.Pronouncedhistopathologicchangesinthecolonicmucosaofinfectedanimalswereobservedduringtheacutephase(days1through3)ofinfection.Electronmicrographsofcolonicepitheliumrevealeddisruptionofthevilliandinternalizedbacteriathatwerenotwithinmembranevacuoles.Duringtheacutephase,C.jejuniwasisolatedfromtheliversof7of9(78%)animals,andbacteriawerevisualizedimmunohistochemicallyintheliversfrom5ofthe7animals(71%)fromwhichC.jejuniwasisolated.AvigoroussystemicandmucosalimmuneresponsetoCampylobacterantigenswaselicitedafterinfectionofferrets.ThedatapresentedcontributetothecurrentknowledgeofthepathogenicityofandimmunologicresponsetoC.jejuniCG8421inferretsandbetterunderstandingofthismodel.

机译：Campylobacterjejuniis1ofthemostcommonentericbacterialpathogensworldwide.Themechanismsofpathogenesisremainobscure，inpartbecauseoflimitationsofsmallanimalmodels.YoungferretsdevelopdiarrheawhenfedC.jejuni，buttheirpathologyandtheimmuneresponseafterinfectionhavenotbeenexaminedindetail.Inthepresentstudy，weexaminedthepathogenesisofC.jejuniCG8421andassociatedimmuneresponsesinferrets.AfteroralinfectionwithC.jejuniCG8421,86.7％oftheanimalsdevelopeddiarrheaandinflammatoryresponsesthatweresimilartothoseseeninhumaninfection.Pronouncedhistopathologicchangesinthecolonicmucosaofinfectedanimalswereobservedduringtheacutephase（days1through3）ofinfection.Electronmicrographsofcolonicepitheliumrevealeddisruptionofthevilliandinternalizedbacteriathatwerenotwithinmembranevacuoles.Duringtheacutephase，C.jejuniwasisolatedfromtheliversof7of9（78％）的动物，andbacteriawerevisualizedimmunohistochemicallyintheliversfrom5ofthe7animals（71％）空肠梭状芽孢杆菌从中分离出来。剧烈的全身性和粘膜免疫反应此数据代表了目前对空肠弯曲杆菌CG8421的致病性和免疫反应的认识，并更好地理解了该模型。

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《Comparative Medicine》 |2009年第4期|共页
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Nemelka Kevin W; Brown Ammon W; Wallace Shannon M; Jones Erika; Asher Ludmila V; Pattarini Dawn; Applebee Lisa; Gilliland Theron C; Guerry Patricia; Baqar Shahida;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Immune response to and histopathology of Campylobacter jejuni infection in ferrets (Mustela putorius furo) [J] . Nemelka KW, Brown AW, Wallace SM, Comparative Medicine . 2009,第4期

机译：对雪貂空肠弯曲杆菌感染的免疫反应和组织病理学（Mustela putorius furo）
2. Cryptococcus gattii infection in a Spanish pet ferret (Mustela putorius furo) and asymptomatic carriage in ferrets and humans from its environment. [J] . Morera N, Juan Salles C, Torres JM, Medical mycology: official publication of the International Society for Human and Animal Mycology . 2011,第7期

机译：西班牙宠物雪貂（Mustela putorius furo）中的gatti隐球菌感染，并且雪貂和人类从其环境中无症状携带。
3. Mycobacterium genavense Infection in a Domestic Ferret (Mustela putorius furo) [J] . De Lorenzi Giorgia, Kamphuisen Karen, Biscontini Giuseppe, Topics in companion animal medicine . 2018,第4期

机译：国内雪貂中的分枝杆菌性感染（Mustela Putorius Furo）
4. Diseases of Domestic Ferrets (Mustela putorius) [C] . Michael M. Garner, Lauren Powers Annual Conference of the Association of Avian Veterinarians . 2010

机译：国内雪貂的疾病（Mustela Putorius）
5. The role of glucose-6-phosphate isomerase in implantation in the ferret (Mustela putorius). [D] . Schulz, Laura Clamon. 2002

机译：葡萄糖-6-磷酸异构酶在雪貂（Mustela putorius）的植入中的作用。
6. Immune Response to and Histopathology of Campylobacter jejuni Infection in Ferrets (Mustela putorius furo) [O] . Kevin W Nemelka, Ammon W Brown, Shannon M Wallace, 2009

机译：对雪貂空肠弯曲杆菌感染的免疫反应和组织病理学
7. Campylobacter pylori subsp. mustelae subsp. nov. Isolated from the Gastric Mucosa of Ferrets (Mustela putorius furo), and an Emended Description of Campylobacter pylori [O] . J. G. FOX, N. S. TAYLOR, P. EDMONDS, 1988

机译：Campylobacter Pylori subsp。 Mustelae subsp。 11月。从雪貂（Mustela Putorius Furo）的胃粘膜和幽门螺杆菌的化妆品描述

Immune Response to and Histopathology of Campylobacter jejuni Infection in Ferrets (Mustela putorius furo)

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